Amyloid-β (Aβ) peptide is commonly found in human Alzheimer's disease (AD) brain and is the main component of Alzheimer amyloid plaques. The predominant forms of Aβ in the human brain are Aβ(1-40) and Aβ(1-42), but Aβ(25-35) fragment, physiologically present in elderly people, is the more toxic region and has been recently found to play a relevant role in AD, due to its peculiar aggregation properties. In this work, we review the current understanding on the conformations and biological activity of Aβ(25-35) exploring aggregation, cytotoxic and neurodegenerative properties of this fundamental Aβ fragment, in order to provide an effective starting point to better approach a pathology spread and problematic as AD.

Millucci, L., Ghezzi, L., Bernardini, G., Santucci, A. (2010). Conformations and biological activities of Amyloid Beta Peptide 25-35. CURRENT PROTEIN & PEPTIDE SCIENCE, 11(1), 54-67 [10.2174/138920310790274626].

Conformations and biological activities of Amyloid Beta Peptide 25-35

MILLUCCI, LIA;GHEZZI, LORENZO;BERNARDINI, GIULIA;SANTUCCI, ANNALISA
2010-01-01

Abstract

Amyloid-β (Aβ) peptide is commonly found in human Alzheimer's disease (AD) brain and is the main component of Alzheimer amyloid plaques. The predominant forms of Aβ in the human brain are Aβ(1-40) and Aβ(1-42), but Aβ(25-35) fragment, physiologically present in elderly people, is the more toxic region and has been recently found to play a relevant role in AD, due to its peculiar aggregation properties. In this work, we review the current understanding on the conformations and biological activity of Aβ(25-35) exploring aggregation, cytotoxic and neurodegenerative properties of this fundamental Aβ fragment, in order to provide an effective starting point to better approach a pathology spread and problematic as AD.
2010
Millucci, L., Ghezzi, L., Bernardini, G., Santucci, A. (2010). Conformations and biological activities of Amyloid Beta Peptide 25-35. CURRENT PROTEIN & PEPTIDE SCIENCE, 11(1), 54-67 [10.2174/138920310790274626].
File in questo prodotto:
File Dimensione Formato  
Conformations and biological activities of Amyloid Beta Peptide 25-35.pdf

non disponibili

Tipologia: Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 464.07 kB
Formato Adobe PDF
464.07 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/20839
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo