The endothelium represents the largest functional organ in the human body playing an active role in vasoregulation, coagulation, inflammation, and microvascular permeability. Endothelium contributes to maintain vascular integrity, intravascular volume, and tissue oxygenation promoting inflammatory network response for local defense and repair. Acid-basis homeostasis is an important physiologic parameter that controls cell function, and changes in pH can influence vascular tone by regulating endothelium and vascular smooth muscle cells. This review presents a current perspective of the effects of intracellular acidosis on the function and the basic regulatory mechanisms of endothelial cells.

Crimi, E., Taccone, F.s., Infante, T., Scolletta, S., Crudele, V., Napoli, C. (2012). Effects of intracellular acidosis on endothelial function: An overview. JOURNAL OF CRITICAL CARE, 27(2), 108-118 [10.1016/j.jcrc.2011.06.001].

Effects of intracellular acidosis on endothelial function: An overview

SCOLLETTA, SABINO;
2012-01-01

Abstract

The endothelium represents the largest functional organ in the human body playing an active role in vasoregulation, coagulation, inflammation, and microvascular permeability. Endothelium contributes to maintain vascular integrity, intravascular volume, and tissue oxygenation promoting inflammatory network response for local defense and repair. Acid-basis homeostasis is an important physiologic parameter that controls cell function, and changes in pH can influence vascular tone by regulating endothelium and vascular smooth muscle cells. This review presents a current perspective of the effects of intracellular acidosis on the function and the basic regulatory mechanisms of endothelial cells.
2012
Crimi, E., Taccone, F.s., Infante, T., Scolletta, S., Crudele, V., Napoli, C. (2012). Effects of intracellular acidosis on endothelial function: An overview. JOURNAL OF CRITICAL CARE, 27(2), 108-118 [10.1016/j.jcrc.2011.06.001].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/18612
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