We have previously reported the development of CB-25 and CB-52, two ligands of CB1 and CB2 cannabinoid receptors. We assessed here their functional activity. The effect of the two compounds on forskolin-induced cAMP formation in intact cells or GTP-g-S binding to cell membranes, and their action on nociception in vivo was determined.
M. G., C., T., B., E., P., A., T., M., V.D.S., Brizzi, A., et al. (2006). In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands. BRITISH JOURNAL OF PHARMACOLOGY, 149, 431-440 [10.1038/sj.bjp.0706888].
In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands
BRIZZI, ANTONELLA;BRIZZI, VITTORIO;
2006-01-01
Abstract
We have previously reported the development of CB-25 and CB-52, two ligands of CB1 and CB2 cannabinoid receptors. We assessed here their functional activity. The effect of the two compounds on forskolin-induced cAMP formation in intact cells or GTP-g-S binding to cell membranes, and their action on nociception in vivo was determined.File | Dimensione | Formato | |
---|---|---|---|
BrJPharmacol 2006.pdf
non disponibili
Tipologia:
Post-print
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
231.84 kB
Formato
Adobe PDF
|
231.84 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/18520
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo