LIM kinases (LIMK) exert their functions by recruiting many macromolecular partners that could contribute to modulate LIMK activity in a positive or negative manner. In addition to proteins that interact with LIMK in human or animal cells and tissues, recent data show that LIMK activity is also influenced by HIV-1 viral proteins. These results suggest new strategies for the treatment of HIV-1 infection, based on the inhibition of LIMK-mediated cofilin inactivation and consequent actin depolymerization. Further efforts are however required to unravel the mechanism by which the virus interferes with LIMK activity and with the right balance of actin remodeling.

Manetti, F. (2012). HIV-1 proteins join the family of LIM kinase partners. New roads open up for HIV-1 treatment. DRUG DISCOVERY TODAY, 17, 81-88 [10.1016/j.drudis.2011.08.004].

HIV-1 proteins join the family of LIM kinase partners. New roads open up for HIV-1 treatment

MANETTI, FABRIZIO
2012-01-01

Abstract

LIM kinases (LIMK) exert their functions by recruiting many macromolecular partners that could contribute to modulate LIMK activity in a positive or negative manner. In addition to proteins that interact with LIMK in human or animal cells and tissues, recent data show that LIMK activity is also influenced by HIV-1 viral proteins. These results suggest new strategies for the treatment of HIV-1 infection, based on the inhibition of LIMK-mediated cofilin inactivation and consequent actin depolymerization. Further efforts are however required to unravel the mechanism by which the virus interferes with LIMK activity and with the right balance of actin remodeling.
2012
Manetti, F. (2012). HIV-1 proteins join the family of LIM kinase partners. New roads open up for HIV-1 treatment. DRUG DISCOVERY TODAY, 17, 81-88 [10.1016/j.drudis.2011.08.004].
File in questo prodotto:
File Dimensione Formato  
2011DDT_LIMK.pdf

non disponibili

Tipologia: Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 481.83 kB
Formato Adobe PDF
481.83 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/11144
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo