Cdk9 is a serine-threonine cdc2-related kinase and its activity is not cell cycle-regulated. Cdk9 function depends on its kinase activity and also on its regulatory units: the T-family cyclins and cyclin K. Recently, several studies confirmed the role of cdk9 in different cellular processes such as signal transduction, basal transcription, HIV-Tat- and MyoD-mediated transcription and differentiation. All the referred data strongly support the concept of a multifunctional protein kinase with specific cytoplasmic and nuclear functions.
Simone, C., Giordano, A. (2001). New insight in cdk9 function: from Tat to MyoD. FRONTIERS IN BIOSCIENCE, 6, 1073-1082 [10.2741/simone].
New insight in cdk9 function: from Tat to MyoD
GIORDANO A.
2001-01-01
Abstract
Cdk9 is a serine-threonine cdc2-related kinase and its activity is not cell cycle-regulated. Cdk9 function depends on its kinase activity and also on its regulatory units: the T-family cyclins and cyclin K. Recently, several studies confirmed the role of cdk9 in different cellular processes such as signal transduction, basal transcription, HIV-Tat- and MyoD-mediated transcription and differentiation. All the referred data strongly support the concept of a multifunctional protein kinase with specific cytoplasmic and nuclear functions.
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https://hdl.handle.net/11365/11008
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