Genetic and Viral landscape in B-Cell Lymphomas : Insights on the EBV Role and Associated Shifts in The Tumour Microenviroment.

The cellular milieau in which lymphoma cells thrive has solely recently become a relevant focus of investigation. The functions of what was belived to be passive bystanders are rapidly becoming elucidated in order to explore potential targets for immunotherapy. Albeit our comprehension of cytogenetic abnormalities and molecular pathways in lymphoma are in advance of solid organ tumors, the same cannot be asserted of the tumor microenvironment. Viruses, being obligate parasites, are under continuous burden in order to survive in front of strong host immune responses. To preserve a replicative advantage , they employ manifold tricks to turn themselves immunologically undetectable. Indeed , EBV may actively reshape lymphoma microenvironment, which is coming into view as a pivotal constituent of the tumor. This talent is at least to some extent due to the elegant strategy evolved by this herpes virus to establish a latent infection in memory B lymphocytes. In point of fact , EBV orchestrates a variety of complex mechanisms facilitating the escape of lymphoma cells from anti-tumor immune responses while sustaining the creation of niches in which tumor cells may survive and prosper. Enlightenment of the contribution of tumor microenvironment in lymphomagenesis is providing the fabric for detecting and validating new therapies that aim both lymphoma cells and crucial microenvironmental components.