Malignant mesothelioma (MM) is a very aggressive asbestos-related cancer, whose incidence is increasing worldwide. Unfortunately, no effective therapies are currently available and the prognosis is extremely poor. Recently, the anti-helminthic drug pyrvinium pamoate has attracted a strong interest for its anti-cancer activity, which has been demonstrated in many cancer models. Considering the previously established inhibitory effect of pyrvinium pamoate on the Wnt/β-catenin pathway and given the important role of this pathway in MM, we investigated the potential anti-tumor activity of this drug in MM cell lines. We observed that pyrvinium pamoate significantly impairs MM cell proliferation, cloning efficiency, migration, and tumor spheroid formation. At the molecular level, our data show that pyrvinium pamoate down-regulates the expression of β-catenin and Wnt-regulates genes. Overall, our study suggests that the repurposing of pyrvinium pamoate for MM treatment could represent a new promising therapeutic approach.

Barbarino, M., Cesari, D., Intruglio, R., Indovina, P., Namagerdi, A., Bertolino, F.M., et al. (2018). Possible repurposing of pyrvinium pamoate for the treatment of mesothelioma: A pre-clinical assessment. JOURNAL OF CELLULAR PHYSIOLOGY, 233(9), 7391-7401 [10.1002/jcp.26579].

Possible repurposing of pyrvinium pamoate for the treatment of mesothelioma: A pre-clinical assessment

Barbarino, Marcella;Cesari, Daniele;Indovina, Paola;RAHMANI, DELARAM;Bellan, Cristiana;Giordano, Antonio
2018-01-01

Abstract

Malignant mesothelioma (MM) is a very aggressive asbestos-related cancer, whose incidence is increasing worldwide. Unfortunately, no effective therapies are currently available and the prognosis is extremely poor. Recently, the anti-helminthic drug pyrvinium pamoate has attracted a strong interest for its anti-cancer activity, which has been demonstrated in many cancer models. Considering the previously established inhibitory effect of pyrvinium pamoate on the Wnt/β-catenin pathway and given the important role of this pathway in MM, we investigated the potential anti-tumor activity of this drug in MM cell lines. We observed that pyrvinium pamoate significantly impairs MM cell proliferation, cloning efficiency, migration, and tumor spheroid formation. At the molecular level, our data show that pyrvinium pamoate down-regulates the expression of β-catenin and Wnt-regulates genes. Overall, our study suggests that the repurposing of pyrvinium pamoate for MM treatment could represent a new promising therapeutic approach.
2018
Barbarino, M., Cesari, D., Intruglio, R., Indovina, P., Namagerdi, A., Bertolino, F.M., et al. (2018). Possible repurposing of pyrvinium pamoate for the treatment of mesothelioma: A pre-clinical assessment. JOURNAL OF CELLULAR PHYSIOLOGY, 233(9), 7391-7401 [10.1002/jcp.26579].
File in questo prodotto:
File Dimensione Formato  
Possible repurposing of pyrvinium pamoate.pdf

non disponibili

Tipologia: PDF editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 3.76 MB
Formato Adobe PDF
3.76 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1055180