Herein we report a domino protocol able to reach regioselectively thiazolylidene systems by combining the reactive peculiarities of both β-amidothioamides (ATAs) and 1,2-diaza-1,3-dienes (DDs). Depending on the reaction conditions and/or the nature of the residue at C4 of the heterodiene system, ATAs can act as hetero-mononucleophiles or hetero-dinucleophiles in the diversified thiazolylidene ring assembly.
Santeusanio, S., Majer, R., Perrulli, F.R., De Crescentini, L., Favi, G., Giorgi, G., et al. (2017). Divergent approach to thiazolylidene derivatives: a perspective on the synthesis of a heterocyclic skeleton from β‑amidothioamides reactivity. JOURNAL OF ORGANIC CHEMISTRY, 82(18), 9773-9778 [10.1021/acs.joc.7b02135].
Divergent approach to thiazolylidene derivatives: a perspective on the synthesis of a heterocyclic skeleton from β‑amidothioamides reactivity
Giorgi, Gianluca;
2017-01-01
Abstract
Herein we report a domino protocol able to reach regioselectively thiazolylidene systems by combining the reactive peculiarities of both β-amidothioamides (ATAs) and 1,2-diaza-1,3-dienes (DDs). Depending on the reaction conditions and/or the nature of the residue at C4 of the heterodiene system, ATAs can act as hetero-mononucleophiles or hetero-dinucleophiles in the diversified thiazolylidene ring assembly.File | Dimensione | Formato | |
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https://hdl.handle.net/11365/1030441