Background:CTX-M-15 is the dominant type of extended-spectrum β-lactamase in clinical isolates. This enzyme constitutes the most widespread enzymes in Tunisia. In this study, we were interested to understand the causes of the evolutionary success of CTX-M-15 in a Tunisian university hospital.Methods:A total of of 72 cefotaxime-resistant Enterobacteriaceae were isolated from newborn patients at the hospital Taher sfar Mahdia in Tunisia and characterized their genetic support by means of molecular techniques.Results:Isolates were clustered into various clonal groups, although most isolates belonged to sequence types ST39 (Klebsiella pneumoniae) and ST131 (Escherichia coli). F replicons (FIA, FIB, and FII) were the most frequently detected replicon types in our collection (91.66%).Conclusion:This is the first report of QnrB-and CTX-M-15-encoding large IncF-type conjugative plasmids in Tunisia.
Lahlaoui, H., DE LUCA, F., Maradei, S., Ben Haj Khalifa, A., Ben Hamouda, H., Kheder, M., et al. (2015). Occurrence of conjugative IncF-type plasmids harboring the bla CTX-M-15 gene in Enterobacteriaceae isolates from newborns in Tunisia. PEDIATRIC RESEARCH, 77(1), 107-110 [10.1038/pr.2014.153].
Occurrence of conjugative IncF-type plasmids harboring the bla CTX-M-15 gene in Enterobacteriaceae isolates from newborns in Tunisia
DE LUCA, FILOMENA;DOCQUIER, JEAN DENIS
2015-01-01
Abstract
Background:CTX-M-15 is the dominant type of extended-spectrum β-lactamase in clinical isolates. This enzyme constitutes the most widespread enzymes in Tunisia. In this study, we were interested to understand the causes of the evolutionary success of CTX-M-15 in a Tunisian university hospital.Methods:A total of of 72 cefotaxime-resistant Enterobacteriaceae were isolated from newborn patients at the hospital Taher sfar Mahdia in Tunisia and characterized their genetic support by means of molecular techniques.Results:Isolates were clustered into various clonal groups, although most isolates belonged to sequence types ST39 (Klebsiella pneumoniae) and ST131 (Escherichia coli). F replicons (FIA, FIB, and FII) were the most frequently detected replicon types in our collection (91.66%).Conclusion:This is the first report of QnrB-and CTX-M-15-encoding large IncF-type conjugative plasmids in Tunisia.
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https://hdl.handle.net/11365/1008811
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