We started to investigate a potential role for EGFR protein expression in predicting the modality of treatment failure in glioblastoma after Stupp protocol, in terms of both time-to-progression (TTP) and pattern of recurrence (PR) [central/in-field (C/I-F) vs. marginal/distant (M/D)]. EGFR expression is statistically correlated with TTP (log-rank test: p = 0.003) and PR (Fisher’s exact test: p = 0.01). Our results seem to suggest that EGFR expression might have a potential role for target contouring of RT volumes in GB patients that deserves further prospective investigations.

Tini, P., Nardone, V., Pirtoli, L. (2017). Is there a potential role for EGFR expression to lead margin reduction in glioblastoma?. JOURNAL OF NEURO-ONCOLOGY, 133, 203-205 [10.1007/s11060-017-2406-z].

Is there a potential role for EGFR expression to lead margin reduction in glioblastoma?

TINI, PAOLO;NARDONE, VALERIO;PIRTOLI, LUIGI
2017-01-01

Abstract

We started to investigate a potential role for EGFR protein expression in predicting the modality of treatment failure in glioblastoma after Stupp protocol, in terms of both time-to-progression (TTP) and pattern of recurrence (PR) [central/in-field (C/I-F) vs. marginal/distant (M/D)]. EGFR expression is statistically correlated with TTP (log-rank test: p = 0.003) and PR (Fisher’s exact test: p = 0.01). Our results seem to suggest that EGFR expression might have a potential role for target contouring of RT volumes in GB patients that deserves further prospective investigations.
2017
Tini, P., Nardone, V., Pirtoli, L. (2017). Is there a potential role for EGFR expression to lead margin reduction in glioblastoma?. JOURNAL OF NEURO-ONCOLOGY, 133, 203-205 [10.1007/s11060-017-2406-z].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1007444