Using a Galleria mellonella animal model, we compared the virulence of two sequence type 258 (ST258) KPC-producing Klebsiella pneumoniae strains, which were representative of the two clades of this clonal lineage, with that of isogenic colistin-resistant mgrB mutants. With both strains, the mgrB mutants did not exhibit modification in virulence. In the G. mellonella model, the clade 1 strain (capsular type cps-1 [wzi29, producing KPC-2]) was significantly more virulent than the clade 2 strain (capsular type cps-2 [wzi154, producing KPC-3]).
Arena, F., De Angelis, L.H., Cannatelli, A., DI PILATO, V., Amorese, M., D'Andrea, M.M., et al. (2016). Colistin resistance caused by inactivation of the MgrB regulator is not associated with decreased virulence of sequence type 258 KPC carbapenemase-producing Klebsiella pneumoniae. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(4), 2509-2512 [10.1128/AAC.02981-15].
Colistin resistance caused by inactivation of the MgrB regulator is not associated with decreased virulence of sequence type 258 KPC carbapenemase-producing Klebsiella pneumoniae
ARENA, FABIO;CANNATELLI, ANTONIO;DI PILATO, VINCENZO;D'ANDREA, MARCO MARIA;GIANI, TOMMASO;ROSSOLINI, GIAN MARIA
2016-01-01
Abstract
Using a Galleria mellonella animal model, we compared the virulence of two sequence type 258 (ST258) KPC-producing Klebsiella pneumoniae strains, which were representative of the two clades of this clonal lineage, with that of isogenic colistin-resistant mgrB mutants. With both strains, the mgrB mutants did not exhibit modification in virulence. In the G. mellonella model, the clade 1 strain (capsular type cps-1 [wzi29, producing KPC-2]) was significantly more virulent than the clade 2 strain (capsular type cps-2 [wzi154, producing KPC-3]).
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https://hdl.handle.net/11365/1001128
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