Sfoglia per Autore
Screen of unfocused libraries identified compounds with direct or synergistic antibacterial activity
2020-01-01 Mugnaini, C.; Sannio, F.; Brizzi, A.; Del Prete, R.; Simone, T.; Ferraro, T.; De Luca, F.; Corelli, F.; Docquier, J. D.
The GABAB receptor positive allosteric modulator COR659: in vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives
2020-01-01 Ferlenghi, Francesca; Maccioni, Paola; Mugnaini, Claudia; Brizzi, Antonella; Fara, Federica; Mostallino, Rafaela; M Paola, Castelli; Colombo, Giancarlo; Mor, Marco; Vacondio, Federica; Corelli, Federico
New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands
2020-01-01 Mugnaini, Claudia; Brizzi, Antonella; Vinciarelli, Giorgia; Paolino, Marco; Corelli, Federico
Synthetic bioactive olivetol-related amides: the influence of the phenolic group in cannabinoid receptor activity
2020-01-01 Brizzi, A.; Aiello, F.; Boccella, S.; Cascio, M. G.; De Petrocellis, L.; Frosini, M.; Gado, F.; Ligresti, A.; Luongo, L.; Marini, P.; Mugnaini, C.; Pessina, F.; Corelli, F.; Maione, S.; Manera, C.; Pertwee, R. G.; Di Marzo, V.
Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators
2020-01-01 Mugnaini, Claudia; Brizzi, Antonella; Mostallino, Rafaela; Paola Castelli, Maria; Corelli, Federico
Design, synthesis, and physicochemical and pharmacological profiling of 7‐Hydroxy-5-oxopyrazolo[4,3‐b]pyridine-6-carboxamide derivatives with antiosteoarthritic activity in vivo
2020-01-01 Mugnaini, Claudia; Kostrzewa, Magdalena; Bryk, Marta; Mokhtar Mahmoud, Ali; Brizzi, Antonella; Lamponi, Stefania; Giorgi, Gianluca; Ferlenghi, Francesca; Vacondio, Federica; Maccioni, Paola; Colombo, Giancarlo; Mor, Marco; Starowicz, Katarzyna; Di Marzo, Vincenzo; Ligresti, Alessia; Corelli, Federico
Suppressing effect of CMPPE, a new positive allosteric modulator of the GABAB receptor, on alcohol self-administration and reinstatement of alcohol seeking in rats
2019-01-01 Maccioni, Paola; Fara, Federica; Lorrai, Irene; Acciaro, Carla; Mugnaini, Claudia; Corelli, Federico; Colombo, Giancarlo
Operant, oral alcohol self-administration: Sex differences in Sardinian alcohol-preferring rats
2019-01-01 Lorrai, Irene; Contini, Andrea; Luigi Gessa, Gian; Mugnaini, Claudia; Corelli, Federico; Colombo, Giancarlo; Maccioni, Paola
A novel highly selective cannabinoid CB2 agonist reduces in vitro growth and TGF-beta release of human glial cell tumors
2019-01-01 Cioni, Chiara; Tassi, Maristella; Marotta, Giuseppe; Mugnaini, Claudia; Corelli, Federico; Annunziata, Pasquale
Inhibiting PNP for the therapy of hyperuricemia in Lesch-Nyhan disease: preliminary in vitro studies with analogues of immucillin-G
2019-01-01 Jacomelli, Gabriella; Baldini, E.; Mugnaini, C.; Micheli, V.; Bernardini, G.; Santucci, A.
Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease
2019-01-01 Mugnaini, Claudia; Rabbito, Alessandro; Brizzi, Antonella; Palombi, Nastasja; Petrosino, Stefania; Verde, Roberta; Di Marzo, Vincenzo; Ligresti, Alessia; Corelli, Federico
Anti-addictive properties of COR659 – Additional pharmacological evidence and comparison with a series of novel analogues
2019-01-01 Maccioni, Paola; Colombo, Giancarlo; Lorrai, Irene; Fara, Federica; Carai, Mauro A. M.; Gessa, Gian Luigi; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico
Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: Involvement of the GABAB and cannabinoid CB1 receptors
2017-01-01 Maccioni, Paola; Colombo, Giancarlo; Lorrai, Irene; Zaru, Alessandro; Carai, Mauro A. M.; Gessa, Gian Luigi; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico
Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis.
2017-01-01 Annunziata, Pasquale; Cioni, Chiara; Mugnaini, Claudia; Corelli, Federico
USO DI DERIVATI DELL’ACIDO 2-AMMINOTIOFEN-3- CARBOSSILICO PER IL TRATTAMENTO DELLE DIPENDENZE DA CIBO
2016-01-01 Colombo, Giancarlo; Carai, Mauro; Gessa Gian, Luigi; Mugnaini, Claudia; Corelli, Federico; Maccioni, Paola
Chemistry of GABAB receptor ligands: focus on agonists and antagonists
2016-01-01 Corelli, Federico; Mugnaini, Claudia
The allosteric modulation of the GABAB receptor: a medicinal chemistry perspective
2016-01-01 Mugnaini, Claudia; Corelli, Federico
Total Synthesis of δ-Sanshool and Analogues Thereof
2016-01-01 Mugnaini, Claudia; Corelli, Federico
Synthesis and biological evaluation of thiophene-based cannabinoid receptor type 2 radiotracers for PET imaging
2016-01-01 Haider, Ahmed; Herde, Adrienne Müller; Slavik, Roger; Weber, Markus; Mugnaini, Claudia; Ligresti, Alessia; Schibli, Roger; Mu, Linjing; Ametamey, Simon Mensah
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility
2016-01-01 Mugnaini, Claudia; Brizzi, Antonella; Ligresti, Alessia; Allarà, Marco; Lamponi, Stefania; Vacondio, Federica; Silva, Claudia; Mor, Marco; Di Marzo, Vincenzo; Corelli, Federico
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| Screen of unfocused libraries identified compounds with direct or synergistic antibacterial activity | 1-gen-2020 | Mugnaini, C.; Sannio, F.; Brizzi, A.; Del Prete, R.; Simone, T.; Ferraro, T.; De Luca, F.; Corelli, F.; Docquier, J. D. | - | |
| The GABAB receptor positive allosteric modulator COR659: in vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives | 1-gen-2020 | Ferlenghi, Francesca; Maccioni, Paola; Mugnaini, Claudia; Brizzi, Antonella; Fara, Federica; Mostallino, Rafaela; M Paola, Castelli; Colombo, Giancarlo; Mor, Marco; Vacondio, Federica; Corelli, Federico | - | |
| New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands | 1-gen-2020 | Mugnaini, Claudia; Brizzi, Antonella; Vinciarelli, Giorgia; Paolino, Marco; Corelli, Federico | - | |
| Synthetic bioactive olivetol-related amides: the influence of the phenolic group in cannabinoid receptor activity | 1-gen-2020 | Brizzi, A.; Aiello, F.; Boccella, S.; Cascio, M. G.; De Petrocellis, L.; Frosini, M.; Gado, F.; Ligresti, A.; Luongo, L.; Marini, P.; Mugnaini, C.; Pessina, F.; Corelli, F.; Maione, S.; Manera, C.; Pertwee, R. G.; Di Marzo, V. | - | |
| Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators | 1-gen-2020 | Mugnaini, Claudia; Brizzi, Antonella; Mostallino, Rafaela; Paola Castelli, Maria; Corelli, Federico | - | |
| Design, synthesis, and physicochemical and pharmacological profiling of 7‐Hydroxy-5-oxopyrazolo[4,3‐b]pyridine-6-carboxamide derivatives with antiosteoarthritic activity in vivo | 1-gen-2020 | Mugnaini, Claudia; Kostrzewa, Magdalena; Bryk, Marta; Mokhtar Mahmoud, Ali; Brizzi, Antonella; Lamponi, Stefania; Giorgi, Gianluca; Ferlenghi, Francesca; Vacondio, Federica; Maccioni, Paola; Colombo, Giancarlo; Mor, Marco; Starowicz, Katarzyna; Di Marzo, Vincenzo; Ligresti, Alessia; Corelli, Federico | - | |
| Suppressing effect of CMPPE, a new positive allosteric modulator of the GABAB receptor, on alcohol self-administration and reinstatement of alcohol seeking in rats | 1-gen-2019 | Maccioni, Paola; Fara, Federica; Lorrai, Irene; Acciaro, Carla; Mugnaini, Claudia; Corelli, Federico; Colombo, Giancarlo | - | |
| Operant, oral alcohol self-administration: Sex differences in Sardinian alcohol-preferring rats | 1-gen-2019 | Lorrai, Irene; Contini, Andrea; Luigi Gessa, Gian; Mugnaini, Claudia; Corelli, Federico; Colombo, Giancarlo; Maccioni, Paola | - | |
| A novel highly selective cannabinoid CB2 agonist reduces in vitro growth and TGF-beta release of human glial cell tumors | 1-gen-2019 | Cioni, Chiara; Tassi, Maristella; Marotta, Giuseppe; Mugnaini, Claudia; Corelli, Federico; Annunziata, Pasquale | - | |
| Inhibiting PNP for the therapy of hyperuricemia in Lesch-Nyhan disease: preliminary in vitro studies with analogues of immucillin-G | 1-gen-2019 | Jacomelli, Gabriella; Baldini, E.; Mugnaini, C.; Micheli, V.; Bernardini, G.; Santucci, A. | - | |
| Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease | 1-gen-2019 | Mugnaini, Claudia; Rabbito, Alessandro; Brizzi, Antonella; Palombi, Nastasja; Petrosino, Stefania; Verde, Roberta; Di Marzo, Vincenzo; Ligresti, Alessia; Corelli, Federico | - | |
| Anti-addictive properties of COR659 – Additional pharmacological evidence and comparison with a series of novel analogues | 1-gen-2019 | Maccioni, Paola; Colombo, Giancarlo; Lorrai, Irene; Fara, Federica; Carai, Mauro A. M.; Gessa, Gian Luigi; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico | - | |
| Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: Involvement of the GABAB and cannabinoid CB1 receptors | 1-gen-2017 | Maccioni, Paola; Colombo, Giancarlo; Lorrai, Irene; Zaru, Alessandro; Carai, Mauro A. M.; Gessa, Gian Luigi; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico | - | |
| Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis. | 1-gen-2017 | Annunziata, Pasquale; Cioni, Chiara; Mugnaini, Claudia; Corelli, Federico | - | |
| USO DI DERIVATI DELL’ACIDO 2-AMMINOTIOFEN-3- CARBOSSILICO PER IL TRATTAMENTO DELLE DIPENDENZE DA CIBO | 1-gen-2016 | Colombo, Giancarlo; Carai, Mauro; Gessa Gian, Luigi; Mugnaini, Claudia; Corelli, Federico; Maccioni, Paola | - | |
| Chemistry of GABAB receptor ligands: focus on agonists and antagonists | 1-gen-2016 | Corelli, Federico; Mugnaini, Claudia | - | |
| The allosteric modulation of the GABAB receptor: a medicinal chemistry perspective | 1-gen-2016 | Mugnaini, Claudia; Corelli, Federico | - | |
| Total Synthesis of δ-Sanshool and Analogues Thereof | 1-gen-2016 | Mugnaini, Claudia; Corelli, Federico | - | |
| Synthesis and biological evaluation of thiophene-based cannabinoid receptor type 2 radiotracers for PET imaging | 1-gen-2016 | Haider, Ahmed; Herde, Adrienne Müller; Slavik, Roger; Weber, Markus; Mugnaini, Claudia; Ligresti, Alessia; Schibli, Roger; Mu, Linjing; Ametamey, Simon Mensah | - | |
| Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility | 1-gen-2016 | Mugnaini, Claudia; Brizzi, Antonella; Ligresti, Alessia; Allarà, Marco; Lamponi, Stefania; Vacondio, Federica; Silva, Claudia; Mor, Marco; Di Marzo, Vincenzo; Corelli, Federico | - |
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