Sfoglia per Autore
In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists
2023-01-01 Romeo, Isabella; Brizzi, Antonella; Pessina, Federica; Ambrosio, Francesca Alessandra; Aiello, Francesca; Belardo, Carmela; Carullo, Gabriele; Costa, Giosuè; De Petrocellis, Luciano; Frosini, Maria; Luongo, Livio; Maramai, Samuele; Paolino, Marco; Moriello, Aniello Schiano; Mugnaini, Claudia; Scorzelli, Francesco; Maione, Sabatino; Corelli, Federico; Di Marzo, Vincenzo; Alcaro, Stefano; Artese, Anna
Development of 1-(2-aminophenyl)pyrrole-based amides acting as human topoisomerase I inhibitors
2023-01-01 Carullo, Gabriele; Mazzotta, Sarah; Ceramella, Jessica; Iacopetta, Domenico; Ramunno, Anna; Rosano, Camillo; Brizzi, Antonella; Campiani, Giuseppe; Aiello, Francesca; Sinicropi, Maria S
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors
2022-01-01 Paolino, Marco; Rullo, Mariagrazia; Maramai, Samuele; de Candia, Modesto; Pisani, Leonardo; Catto, Marco; Mugnaini, Claudia; Brizzi, Antonella; Cappelli, Andrea; Olivucci, Massimo; Corelli, Federico; Altomare, Cosimo D
Lipoic/Capsaicin-Related Amides: Synthesis and Biological Characterization of New TRPV1 Agonists Endowed with Protective Properties against Oxidative Stress
2022-01-01 Brizzi, Antonella; Maramai, Samuele; Aiello, Francesca; Baratto, Maria Camilla; Corelli, Federico; Mugnaini, Claudia; Paolino, Marco; Scorzelli, Francesco; Aldinucci, Carlo; De Petrocellis, Luciano; Signorini, Cinzia; Pessina, Federica
Optimization of Pyrazole Compounds as Antibiotic Adjuvants Active against Colistin- and Carbapenem-Resistant Acinetobacter baumannii
2022-01-01 Sannio, Filomena; Brizzi, Antonella; Del Prete, Rosita; Avigliano, Marialuce; Simone, Tiziana; Pagli, Carlotta; Ferraro, Teresa; De Luca, Filomena; Paolino, Marco; Corelli, Federico; Mugnaini, Claudia; Docquier, Jean-Denis
Synthesis of pyrazolo[1,5-a]pyrimidine ring as a possible bioisosteric replacement of the 5-(1H-pyrrol-1-yl)pyrazole scaffold
2022-01-01 Mugnaini, Claudia; Pasculini, Livia; Pagli, Carlotta; Brizzi, Antonella; Paolino, Marco; Gianibbi, Beatrice; Corelli, Federico
Suppressing effect of the novel positive allosteric modulator of the GABAB receptor, COR659, on locomotor hyperactivity induced by different drugs of abuse
2021-01-01 Lobina, Carla; Maccioni, Paola; Lorrai, Irene; Zaru, Alessandro; Collu, Maria; Carai, Mauro A. M.; Brizzi, Antonella; Mugnaini, Claudia; Luigi Gessa, Gian; Corelli, Federico; Colombo, Giancarlo
Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway
2021-01-01 Mazzotta, Sarah; Governa, Paolo; Borgonetti, Vittoria; Marcolongo, Paola; Nanni, Claudio; Gamberucci, Alessandra; Manetti, Fabrizio; Pessina, Federica; Carullo, Gabriele; Brizzi, Antonella; Aiello, Francesca
GPR120/FFAR4 pharmacology: focus on agonists in Type 2 diabetes mellitus drug discovery
2021-01-01 Carullo, G.; Mazzotta, S.; Vega-Holm, M.; Iglesias-Guerra, F.; Vega-Perez, J. M.; Aiello, F.; Brizzi, A.
2-hydroxy-4-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation
2021-01-01 Brizzi, A.; Trezza, A.; Spiga, O.; Maramai, S.; Scorzelli, F.; Saponara, S.; Fusi, F.
A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels
2021-01-01 Carullo, G.; Ahmed, A.; Trezza, A.; Spiga, O.; Brizzi, A.; Saponara, S.; Fusi, F.; Aiello, F.
Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7‐Hydroxy-5-oxopyrazolo[4,3‐b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo
2020-01-01 Mugnaini, Claudia; Kostrzewa, Magdalena; Bryk, Marta; Mokhtar Mahmoud, Ali; Brizzi, Antonella; Lamponi, Stefania; Giorgi, Gianluca; Ferlenghi, Francesca; Vacondio, Federica; Maccioni, Paola; Colombo, Giancarlo; Mor, Marco; Starowicz, Katarzyna; Di Marzo, Vincenzo; Ligresti, Alessia; Corelli, Federico
Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators
2020-01-01 Mugnaini, Claudia; Brizzi, Antonella; Mostallino, Rafaela; Paola Castelli, Maria; Corelli, Federico
New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands
2020-01-01 Mugnaini, Claudia; Brizzi, Antonella; Vinciarelli, Giorgia; Paolino, Marco; Corelli, Federico
The GABAB receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives
2020-01-01 Ferlenghi, Francesca; Maccioni, Paola; Mugnaini, Claudia; Brizzi, Antonella; Fara, Federica; Mostallino, Rafaela; M Paola, Castelli; Colombo, Giancarlo; Mor, Marco; Vacondio, Federica; Corelli, Federico
Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83
2020-01-01 Cerretani, Daniela; Collodel, Giulia; Brizzi, Antonella; Fiaschi, ANNA IDA; Menchiari, Andrea; Moretti, Elena; Moltoni, Laura; Micheli, Lucia
Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators
2020-01-01 Carullo, G.; Ahmed, A.; Trezza, A.; Spiga, O.; Brizzi, A.; Saponara, S.; Fusi, F.; Aiello, F.
Computational drug repurposing for the identification of SARS-CoV-2 main protease inhibitors
2020-01-01 Fiorucci, Diego; Milletti, Eva; Orofino, Francesco; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico
Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes
2020-01-01 Mazzotta, S.; Carullo, G.; Schiano Moriello, A.; Amodeo, P.; Di Marzo, V.; Vega-Holm, M.; Vitale, R. M.; Aiello, F.; Brizzi, A.; De Petrocellis, L.
Targeting neuropathic pain: Pathobiology, current treatment and peptidomimetics as a new therapeutic opportunity
2020-01-01 Caroleo, M. C.; Brizzi, A.; De Rosa, M.; Pandey, A.; Gallelli, L.; Badolato, M.; Carullo, G.; Cione, E.
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists | 1-gen-2023 | Romeo, Isabella; Brizzi, Antonella; Pessina, Federica; Ambrosio, Francesca Alessandra; Aiello, Francesca; Belardo, Carmela; Carullo, Gabriele; Costa, Giosuè; De Petrocellis, Luciano; Frosini, Maria; Luongo, Livio; Maramai, Samuele; Paolino, Marco; Moriello, Aniello Schiano; Mugnaini, Claudia; Scorzelli, Francesco; Maione, Sabatino; Corelli, Federico; Di Marzo, Vincenzo; Alcaro, Stefano; Artese, Anna | - | |
| Development of 1-(2-aminophenyl)pyrrole-based amides acting as human topoisomerase I inhibitors | 1-gen-2023 | Carullo, Gabriele; Mazzotta, Sarah; Ceramella, Jessica; Iacopetta, Domenico; Ramunno, Anna; Rosano, Camillo; Brizzi, Antonella; Campiani, Giuseppe; Aiello, Francesca; Sinicropi, Maria S | - | |
| Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors | 1-gen-2022 | Paolino, Marco; Rullo, Mariagrazia; Maramai, Samuele; de Candia, Modesto; Pisani, Leonardo; Catto, Marco; Mugnaini, Claudia; Brizzi, Antonella; Cappelli, Andrea; Olivucci, Massimo; Corelli, Federico; Altomare, Cosimo D | - | |
| Lipoic/Capsaicin-Related Amides: Synthesis and Biological Characterization of New TRPV1 Agonists Endowed with Protective Properties against Oxidative Stress | 1-gen-2022 | Brizzi, Antonella; Maramai, Samuele; Aiello, Francesca; Baratto, Maria Camilla; Corelli, Federico; Mugnaini, Claudia; Paolino, Marco; Scorzelli, Francesco; Aldinucci, Carlo; De Petrocellis, Luciano; Signorini, Cinzia; Pessina, Federica | - | |
| Optimization of Pyrazole Compounds as Antibiotic Adjuvants Active against Colistin- and Carbapenem-Resistant Acinetobacter baumannii | 1-gen-2022 | Sannio, Filomena; Brizzi, Antonella; Del Prete, Rosita; Avigliano, Marialuce; Simone, Tiziana; Pagli, Carlotta; Ferraro, Teresa; De Luca, Filomena; Paolino, Marco; Corelli, Federico; Mugnaini, Claudia; Docquier, Jean-Denis | - | |
| Synthesis of pyrazolo[1,5-a]pyrimidine ring as a possible bioisosteric replacement of the 5-(1H-pyrrol-1-yl)pyrazole scaffold | 1-gen-2022 | Mugnaini, Claudia; Pasculini, Livia; Pagli, Carlotta; Brizzi, Antonella; Paolino, Marco; Gianibbi, Beatrice; Corelli, Federico | - | |
| Suppressing effect of the novel positive allosteric modulator of the GABAB receptor, COR659, on locomotor hyperactivity induced by different drugs of abuse | 1-gen-2021 | Lobina, Carla; Maccioni, Paola; Lorrai, Irene; Zaru, Alessandro; Collu, Maria; Carai, Mauro A. M.; Brizzi, Antonella; Mugnaini, Claudia; Luigi Gessa, Gian; Corelli, Federico; Colombo, Giancarlo | - | |
| Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway | 1-gen-2021 | Mazzotta, Sarah; Governa, Paolo; Borgonetti, Vittoria; Marcolongo, Paola; Nanni, Claudio; Gamberucci, Alessandra; Manetti, Fabrizio; Pessina, Federica; Carullo, Gabriele; Brizzi, Antonella; Aiello, Francesca | - | |
| GPR120/FFAR4 pharmacology: focus on agonists in Type 2 diabetes mellitus drug discovery | 1-gen-2021 | Carullo, G.; Mazzotta, S.; Vega-Holm, M.; Iglesias-Guerra, F.; Vega-Perez, J. M.; Aiello, F.; Brizzi, A. | - | |
| 2-hydroxy-4-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation | 1-gen-2021 | Brizzi, A.; Trezza, A.; Spiga, O.; Maramai, S.; Scorzelli, F.; Saponara, S.; Fusi, F. | - | |
| A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels | 1-gen-2021 | Carullo, G.; Ahmed, A.; Trezza, A.; Spiga, O.; Brizzi, A.; Saponara, S.; Fusi, F.; Aiello, F. | - | |
| Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7‐Hydroxy-5-oxopyrazolo[4,3‐b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo | 1-gen-2020 | Mugnaini, Claudia; Kostrzewa, Magdalena; Bryk, Marta; Mokhtar Mahmoud, Ali; Brizzi, Antonella; Lamponi, Stefania; Giorgi, Gianluca; Ferlenghi, Francesca; Vacondio, Federica; Maccioni, Paola; Colombo, Giancarlo; Mor, Marco; Starowicz, Katarzyna; Di Marzo, Vincenzo; Ligresti, Alessia; Corelli, Federico | - | |
| Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators | 1-gen-2020 | Mugnaini, Claudia; Brizzi, Antonella; Mostallino, Rafaela; Paola Castelli, Maria; Corelli, Federico | - | |
| New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands | 1-gen-2020 | Mugnaini, Claudia; Brizzi, Antonella; Vinciarelli, Giorgia; Paolino, Marco; Corelli, Federico | - | |
| The GABAB receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives | 1-gen-2020 | Ferlenghi, Francesca; Maccioni, Paola; Mugnaini, Claudia; Brizzi, Antonella; Fara, Federica; Mostallino, Rafaela; M Paola, Castelli; Colombo, Giancarlo; Mor, Marco; Vacondio, Federica; Corelli, Federico | - | |
| Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83 | 1-gen-2020 | Cerretani, Daniela; Collodel, Giulia; Brizzi, Antonella; Fiaschi, ANNA IDA; Menchiari, Andrea; Moretti, Elena; Moltoni, Laura; Micheli, Lucia | - | |
| Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators | 1-gen-2020 | Carullo, G.; Ahmed, A.; Trezza, A.; Spiga, O.; Brizzi, A.; Saponara, S.; Fusi, F.; Aiello, F. | - | |
| Computational drug repurposing for the identification of SARS-CoV-2 main protease inhibitors | 1-gen-2020 | Fiorucci, Diego; Milletti, Eva; Orofino, Francesco; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico | - | |
| Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes | 1-gen-2020 | Mazzotta, S.; Carullo, G.; Schiano Moriello, A.; Amodeo, P.; Di Marzo, V.; Vega-Holm, M.; Vitale, R. M.; Aiello, F.; Brizzi, A.; De Petrocellis, L. | - | |
| Targeting neuropathic pain: Pathobiology, current treatment and peptidomimetics as a new therapeutic opportunity | 1-gen-2020 | Caroleo, M. C.; Brizzi, A.; De Rosa, M.; Pandey, A.; Gallelli, L.; Badolato, M.; Carullo, G.; Cione, E. | - |
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