Sfoglia per Autore
Indole-2-Carboxamide as an Effective Scaffold for the Design of New TRPV1 Agonists
2025-01-01 Maramai, Samuele; Mugnaini, Claudia; Paolino, Marco; Schiano Moriello, Aniello; De Petrocellis, Luciano; Corelli, Federico; Aiello, Francesca; Brizzi, Antonella
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor
2025-01-01 Poggialini, Federica; Governa, Paolo; Vagaggini, Chiara; Maramai, Samuele; Lamponi, Stefania; Mugnaini, Claudia; Brizzi, Antonella; Purgatorio, Rosa; de Candia, Modesto; Catto, Marco; Dreassi, Elena; Manetti, Fabrizio; Corelli, Federico; Altomare, Cosimo Damiano; Cappelli, Andrea; Paolino, Marco
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo
2024-01-01 Mugnaini, Claudia; Brizzi, Antonella; Paolino, Marco; Scarselli, Enrico; Castelli, Riccardo; de Candia, Modesto; Gambacorta, Nicola; Nicolotti, Orazio; Kostrzewa, Magdalena; Kumar, Poulami; Mahmoud, Ali Mokhtar; Borgonetti, Vittoria; Iannotta, Monica; Morace, Andrea; Galeotti, Nicoletta; Maione, Sabatino; Altomare, Cosimo D.; Ligresti, Alessia; Corelli, Federico
Synthesis of some novel 1-aryl-1H-1,2,3-triazole-4-carboxamides and ethyl 1-aryl-5-(1,2,3-triazol-1-yl)-1H-pyrazole-4-carboxylates
2023-01-01 Avigliano, Marialuce; Francesco, Debora De; Brizzi, Antonella; Paolino, Marco; Corelli, Federico; Mugnaini, Claudia
Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor
2023-01-01 Mugnaini, Claudia; Kostrzewa, Magdalena; Casini, Marta; Kumar, Poulami; Catallo, Valeria; Allarà, Marco; Guastaferro, Laura; Brizzi, Antonella; Paolino, Marco; Tafi, Andrea; Kapatais, Christelos; Giorgi, Gianluca; Vacondio, Federica; Mor, Marco; Corelli, Federico; Ligresti, Alessia
The Selective CB2 Agonist COR167 Reduced Symptoms in a Mice Model of Trauma-Induced Peripheral Neuropathy through HDAC-1 Inhibition
2023-01-01 Borgonetti, V.; Mugnaini, C.; Corelli, F.; Galeotti, N.
In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists
2023-01-01 Romeo, Isabella; Brizzi, Antonella; Pessina, Federica; Ambrosio, Francesca Alessandra; Aiello, Francesca; Belardo, Carmela; Carullo, Gabriele; Costa, Giosuè; De Petrocellis, Luciano; Frosini, Maria; Luongo, Livio; Maramai, Samuele; Paolino, Marco; Moriello, Aniello Schiano; Mugnaini, Claudia; Scorzelli, Francesco; Maione, Sabatino; Corelli, Federico; Di Marzo, Vincenzo; Alcaro, Stefano; Artese, Anna
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity
2023-01-01 Paolino, M.; de Candia, M.; Purgatorio, R.; Catto, M.; Saletti, M.; Tondo, A. R.; Nicolotti, O.; Cappelli, A.; Brizzi, A.; Mugnaini, C.; Corelli, F.; Altomare, C. D.
Lipoic/Capsaicin-Related Amides: Synthesis and Biological Characterization of New TRPV1 Agonists Endowed with Protective Properties against Oxidative Stress
2022-01-01 Brizzi, Antonella; Maramai, Samuele; Aiello, Francesca; Baratto, Maria Camilla; Corelli, Federico; Mugnaini, Claudia; Paolino, Marco; Scorzelli, Francesco; Aldinucci, Carlo; De Petrocellis, Luciano; Signorini, Cinzia; Pessina, Federica
In silico multi-target approach revealed potential lead compounds as scaffold for the synthesis of chemical analogues targeting SARS-CoV-2
2022-01-01 Trezza, Alfonso; Mugnaini, Claudia; Corelli, Federico; Santucci, Annalisa; Spiga, Ottavia
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors
2022-01-01 Paolino, Marco; Rullo, Mariagrazia; Maramai, Samuele; de Candia, Modesto; Pisani, Leonardo; Catto, Marco; Mugnaini, Claudia; Brizzi, Antonella; Cappelli, Andrea; Olivucci, Massimo; Corelli, Federico; Altomare, Cosimo D
Synthesis of pyrazolo[1,5-a]pyrimidine ring as a possible bioisosteric replacement of the 5-(1H-pyrrol-1-yl)pyrazole scaffold
2022-01-01 Mugnaini, Claudia; Pasculini, Livia; Pagli, Carlotta; Brizzi, Antonella; Paolino, Marco; Gianibbi, Beatrice; Corelli, Federico
Optimization of Pyrazole Compounds as Antibiotic Adjuvants Active against Colistin- and Carbapenem-Resistant Acinetobacter baumannii
2022-01-01 Sannio, Filomena; Brizzi, Antonella; Del Prete, Rosita; Avigliano, Marialuce; Simone, Tiziana; Pagli, Carlotta; Ferraro, Teresa; De Luca, Filomena; Paolino, Marco; Corelli, Federico; Mugnaini, Claudia; Docquier, Jean-Denis
Suppressing effect of the novel positive allosteric modulator of the GABAB receptor, COR659, on locomotor hyperactivity induced by different drugs of abuse
2021-01-01 Lobina, Carla; Maccioni, Paola; Lorrai, Irene; Zaru, Alessandro; Collu, Maria; Carai, Mauro A. M.; Brizzi, Antonella; Mugnaini, Claudia; Luigi Gessa, Gian; Corelli, Federico; Colombo, Giancarlo
Computational drug repurposing for the identification of SARS-CoV-2 main protease inhibitors
2021-01-01 Fiorucci, Diego; Milletti, Eva; Orofino, Francesco; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico
COR758, a negative allosteric modulator of GABAB receptors
2021-01-01 Porcu, Alessandra; Mostallino, Rafaela; Serra, Valeria; Melis, Miriam; Sogos, Valeria; Beggiato, Sarah; Ferraro, Luca; Manetti, Fabrizio; Gianibbi, Beatrice; Bettler, Bernhard; Corelli, Federico; Mugnaini, Claudia; Castelli, M. Paola
Has a “Chemical Magic” Opened up New Prospects for Glaucoma?
2021-01-01 Corelli, Federico
Viral Envelope Membrane: A Special Entry Pathway and a Promising Drug Target
2021-01-01 Palombi, Nastasja; Brai, Annalaura; Gerace, Martina; DI MARIA, Salvatore; Orofino, Francesco; Corelli, Federico
Synthetic bioactive olivetol-related amides: the influence of the phenolic group in cannabinoid receptor activity
2020-01-01 Brizzi, A.; Aiello, F.; Boccella, S.; Cascio, M. G.; De Petrocellis, L.; Frosini, M.; Gado, F.; Ligresti, A.; Luongo, L.; Marini, P.; Mugnaini, C.; Pessina, F.; Corelli, F.; Maione, S.; Manera, C.; Pertwee, R. G.; Di Marzo, V.
Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators
2020-01-01 Mugnaini, Claudia; Brizzi, Antonella; Mostallino, Rafaela; Paola Castelli, Maria; Corelli, Federico
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| Indole-2-Carboxamide as an Effective Scaffold for the Design of New TRPV1 Agonists | 1-gen-2025 | Maramai, Samuele; Mugnaini, Claudia; Paolino, Marco; Schiano Moriello, Aniello; De Petrocellis, Luciano; Corelli, Federico; Aiello, Francesca; Brizzi, Antonella | - | |
| Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor | 1-gen-2025 | Poggialini, Federica; Governa, Paolo; Vagaggini, Chiara; Maramai, Samuele; Lamponi, Stefania; Mugnaini, Claudia; Brizzi, Antonella; Purgatorio, Rosa; de Candia, Modesto; Catto, Marco; Dreassi, Elena; Manetti, Fabrizio; Corelli, Federico; Altomare, Cosimo Damiano; Cappelli, Andrea; Paolino, Marco | - | |
| Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo | 1-gen-2024 | Mugnaini, Claudia; Brizzi, Antonella; Paolino, Marco; Scarselli, Enrico; Castelli, Riccardo; de Candia, Modesto; Gambacorta, Nicola; Nicolotti, Orazio; Kostrzewa, Magdalena; Kumar, Poulami; Mahmoud, Ali Mokhtar; Borgonetti, Vittoria; Iannotta, Monica; Morace, Andrea; Galeotti, Nicoletta; Maione, Sabatino; Altomare, Cosimo D.; Ligresti, Alessia; Corelli, Federico | - | |
| Synthesis of some novel 1-aryl-1H-1,2,3-triazole-4-carboxamides and ethyl 1-aryl-5-(1,2,3-triazol-1-yl)-1H-pyrazole-4-carboxylates | 1-gen-2023 | Avigliano, Marialuce; Francesco, Debora De; Brizzi, Antonella; Paolino, Marco; Corelli, Federico; Mugnaini, Claudia | - | |
| Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor | 1-gen-2023 | Mugnaini, Claudia; Kostrzewa, Magdalena; Casini, Marta; Kumar, Poulami; Catallo, Valeria; Allarà, Marco; Guastaferro, Laura; Brizzi, Antonella; Paolino, Marco; Tafi, Andrea; Kapatais, Christelos; Giorgi, Gianluca; Vacondio, Federica; Mor, Marco; Corelli, Federico; Ligresti, Alessia | - | |
| The Selective CB2 Agonist COR167 Reduced Symptoms in a Mice Model of Trauma-Induced Peripheral Neuropathy through HDAC-1 Inhibition | 1-gen-2023 | Borgonetti, V.; Mugnaini, C.; Corelli, F.; Galeotti, N. | - | |
| In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists | 1-gen-2023 | Romeo, Isabella; Brizzi, Antonella; Pessina, Federica; Ambrosio, Francesca Alessandra; Aiello, Francesca; Belardo, Carmela; Carullo, Gabriele; Costa, Giosuè; De Petrocellis, Luciano; Frosini, Maria; Luongo, Livio; Maramai, Samuele; Paolino, Marco; Moriello, Aniello Schiano; Mugnaini, Claudia; Scorzelli, Francesco; Maione, Sabatino; Corelli, Federico; Di Marzo, Vincenzo; Alcaro, Stefano; Artese, Anna | - | |
| Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity | 1-gen-2023 | Paolino, M.; de Candia, M.; Purgatorio, R.; Catto, M.; Saletti, M.; Tondo, A. R.; Nicolotti, O.; Cappelli, A.; Brizzi, A.; Mugnaini, C.; Corelli, F.; Altomare, C. D. | - | |
| Lipoic/Capsaicin-Related Amides: Synthesis and Biological Characterization of New TRPV1 Agonists Endowed with Protective Properties against Oxidative Stress | 1-gen-2022 | Brizzi, Antonella; Maramai, Samuele; Aiello, Francesca; Baratto, Maria Camilla; Corelli, Federico; Mugnaini, Claudia; Paolino, Marco; Scorzelli, Francesco; Aldinucci, Carlo; De Petrocellis, Luciano; Signorini, Cinzia; Pessina, Federica | - | |
| In silico multi-target approach revealed potential lead compounds as scaffold for the synthesis of chemical analogues targeting SARS-CoV-2 | 1-gen-2022 | Trezza, Alfonso; Mugnaini, Claudia; Corelli, Federico; Santucci, Annalisa; Spiga, Ottavia | - | |
| Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors | 1-gen-2022 | Paolino, Marco; Rullo, Mariagrazia; Maramai, Samuele; de Candia, Modesto; Pisani, Leonardo; Catto, Marco; Mugnaini, Claudia; Brizzi, Antonella; Cappelli, Andrea; Olivucci, Massimo; Corelli, Federico; Altomare, Cosimo D | - | |
| Synthesis of pyrazolo[1,5-a]pyrimidine ring as a possible bioisosteric replacement of the 5-(1H-pyrrol-1-yl)pyrazole scaffold | 1-gen-2022 | Mugnaini, Claudia; Pasculini, Livia; Pagli, Carlotta; Brizzi, Antonella; Paolino, Marco; Gianibbi, Beatrice; Corelli, Federico | - | |
| Optimization of Pyrazole Compounds as Antibiotic Adjuvants Active against Colistin- and Carbapenem-Resistant Acinetobacter baumannii | 1-gen-2022 | Sannio, Filomena; Brizzi, Antonella; Del Prete, Rosita; Avigliano, Marialuce; Simone, Tiziana; Pagli, Carlotta; Ferraro, Teresa; De Luca, Filomena; Paolino, Marco; Corelli, Federico; Mugnaini, Claudia; Docquier, Jean-Denis | - | |
| Suppressing effect of the novel positive allosteric modulator of the GABAB receptor, COR659, on locomotor hyperactivity induced by different drugs of abuse | 1-gen-2021 | Lobina, Carla; Maccioni, Paola; Lorrai, Irene; Zaru, Alessandro; Collu, Maria; Carai, Mauro A. M.; Brizzi, Antonella; Mugnaini, Claudia; Luigi Gessa, Gian; Corelli, Federico; Colombo, Giancarlo | - | |
| Computational drug repurposing for the identification of SARS-CoV-2 main protease inhibitors | 1-gen-2021 | Fiorucci, Diego; Milletti, Eva; Orofino, Francesco; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico | - | |
| COR758, a negative allosteric modulator of GABAB receptors | 1-gen-2021 | Porcu, Alessandra; Mostallino, Rafaela; Serra, Valeria; Melis, Miriam; Sogos, Valeria; Beggiato, Sarah; Ferraro, Luca; Manetti, Fabrizio; Gianibbi, Beatrice; Bettler, Bernhard; Corelli, Federico; Mugnaini, Claudia; Castelli, M. Paola | - | |
| Has a “Chemical Magic” Opened up New Prospects for Glaucoma? | 1-gen-2021 | Corelli, Federico | - | |
| Viral Envelope Membrane: A Special Entry Pathway and a Promising Drug Target | 1-gen-2021 | Palombi, Nastasja; Brai, Annalaura; Gerace, Martina; DI MARIA, Salvatore; Orofino, Francesco; Corelli, Federico | - | |
| Synthetic bioactive olivetol-related amides: the influence of the phenolic group in cannabinoid receptor activity | 1-gen-2020 | Brizzi, A.; Aiello, F.; Boccella, S.; Cascio, M. G.; De Petrocellis, L.; Frosini, M.; Gado, F.; Ligresti, A.; Luongo, L.; Marini, P.; Mugnaini, C.; Pessina, F.; Corelli, F.; Maione, S.; Manera, C.; Pertwee, R. G.; Di Marzo, V. | - | |
| Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators | 1-gen-2020 | Mugnaini, Claudia; Brizzi, Antonella; Mostallino, Rafaela; Paola Castelli, Maria; Corelli, Federico | - |
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