Sfoglia per Autore
Characterization of COR627 and COR628, two novel positive allosteric modulators of the GABA B receptor
2012-01-01 Castelli, M. P.; Casu, A.; Casti, P.; Lobina, C.; Carai, M. A. M.; Colombo, G.; Solinas, M.; Giunta, D.; Mugnaini, Claudia; Pasquini, Serena; Tafi, Andrea; Brogi, Simone; Gessa, G. L.; Corelli, Federico
The bioisosteric concept applied to cannabinoid ligands
2012-01-01 Mugnaini, Claudia; Pasquini, Serena; Corelli, Federico
Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach.
2012-01-01 Mugnaini, Claudia; Nocerino, S.; Pedani, Valentina; Pasquini, Serena; Tafi, Andrea; De Chiaro, M.; Bellucci, L.; Valoti, Massimo; Guida, F.; Luongo, L.; Dragoni, Stefania; Ligresti, A.; Rosenberg, A.; Bolognini, D.; Cascio, M. G.; Pertwee, R. G.; Moaddel, R.; Maione, S.; Di Marzo, V.; Corelli, Federico
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 6. Synthesis and Pharmacological Evaluation of 7-Substituted 4-Quinolone-3-carboxamide Derivatives as High Affinity Ligands for Cannabinoid Receptors
2012-01-01 Pasquini, Serena; DE ROSA, Maria; Ligresti, A.; Mugnaini, Claudia; Brizzi, Antonella; Caradonna, N. P.; Cascio, M. G.; Bolognini, D.; Pertwee, R. G.; Di Marzo, V.; Corelli, Federico
Design, Synthesis, and Pharmacological Characterization of Indole-3-ylacetamides, Indole-3-yloxoacetamides, and Indole-3-ylcarboxamides: Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists
2012-01-01 Pasquini, Serena; Mugnaini, Claudia; Ligresti, A.; Tafi, Andrea; Brogi, Simone; Falciani, C.; Pedani, Valentina; Pesco, N.; Guida, F.; Luongo, L.; Varani, K.; Borea, P. A.; Maione, S.; Di Marzo, V.; Corelli, Federico
A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury
2012-01-01 Contartese, Antonella; Valoti, Massimo; Corelli, Federico; Pasquini, Serena; Mugnaini, Claudia; Pessina, Federica; Aldinucci, Carlo; Sgaragli, GIAN PIETRO; Frosini, Maria
Comparison of the effect of the positive allosteric modulator of the GABAb receptor, GS39783, on alcohol self-administration in three different lines of alcohol-preferring rats
2012-01-01 Maccioni, P.; Zaru, A.; Loi, B.; Lobina, C.; Carai, M. A. M.; Gessa, G. L.; Capra, A.; Mugnaini, Claudia; Pasquini, Serena; Corelli, Federico; Hyytiä, P.; Lumeng, L.; Colombo, G.
1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: An effective scaffold for the design of either CB1 and CB2 receptor ligands
2011-01-01 Piscitelli, F; Ligresti, A; LA REGINA, G; Gatti, V; Brizzi, Antonella; Pasquini, Serena; Allarà, M; CARAI M. A., M; Novellino, E; Colombo, G; DI MARZO, V; Corelli, Federico; Silvestri, R.
Three-Dimensional Quantitative Structure-Selectivity Relationships (3D-QSSR) Analysis Guided Rational Design of a Highly Selective Ligand for the Cannabinoid Receptor 2
2011-01-01 Brogi, Simone; Corelli, Federico; V., DI MARZO; A., Ligresti; Mugnaini, Claudia; Pasquini, Serena; Tafi, Andrea
Activation of the GABAB receptor prevents nicotine-induced locomotor stimulation in mice
2011-01-01 Lobina, C.; Carai, M. A. M.; Froestl, W.; Mugnaini, Claudia; Pasquini, Serena; Corelli, Federico; G. e. s. s. a. G., L.; Colombo, G.
Regioselective functionalization of quinolin-4(1H)-ones via sequential palladium-catalyzed reactions
2011-01-01 Mugnaini, Claudia; Falciani, Chiara; DE ROSA, Maria; Brizzi, Antonella; Pasquini, Serena; Corelli, Federico
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 4. Identification of New Potent and Selective Ligands for the Cannabinoid Type 2 Receptor with Diverse Substitution Patterns and Antihyperalgesic Effects in Mice.
2011-01-01 Pasquini, Serena; DE ROSA, Maria; Pedani, Valentina; Mugnaini, Claudia; Guida, F; Luongo, L; DE CHIARO, M; Maione, S; Dragoni, Stefania; Frosini, Maria; Ligresti, A; DI MARZO, V; Corelli, Federico
Synthesis and biological evaluation of New N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands
2010-01-01 Romano, Silvestri; Alessia, Ligresti; GIUSEPPE LA, Regina; Francesco, Piscitelli; Valerio, Gatti; Antonio, Lavecchia; Pasquini, Serena; Marco, Allarà; Noemi, Fantini; MAURO ANTONIO MARIA, Carai; Chiara, Bigogno; MARCO GIULIO, Rozio; Roberta, Sinisi; Ettore, Novellino; Giancarlo, Colombo; VINCENZO DI, Marzo; Giulio, Dondio; Brizzi, Antonella; Corelli, Federico
In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB2 receptor inverse agonists
2010-01-01 M. G., Cascio; D., Bolognini; R. G., Pertwee; E., Palazzo; Corelli, Federico; Pasquini, Serena; V., DI MARZO; S., Maione
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 3. Synthesis, Structure-Affinity Relationships, and Pharmacological Characterization of 6-Substituted 4-Quinolone-3-carboxamides as Highly Selective Cannabinoid-2 Receptor Ligands
2010-01-01 Pasquini, Serena; Ligresti, A; Mugnaini, Claudia; Semeraro, Teresa; Cicione, L; DE ROSA, Maria; Guida, F; Luongo, L; DE CHIARO, M; CASCIO M., G; Bolognini, D; Marini, P; Pertwee, R; Maione, S; DI MARZO, V; Corelli, Federico
Reduction by the positive allosteric modulator of the GABAB receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure
2010-01-01 Maccioni, P; Flore, P; Carai, M. A. M.; Mugnaini, Claudia; Pasquini, Serena; Corelli, Federico; Gessa, G. L.; Colombo, G.
The 4-Quinolone-3-carboxylic Acid Motif as a Multivalent Scaffold in Medicinal Chemistry
2009-01-01 Mugnaini, Claudia; Pasquini, Serena; Corelli, Federico
New Resorcinol-Anandamide "Hybrids" as Potent Cannabinoid Receptor Ligands Endowed with antinociceptive activity in vivo
2009-01-01 Brizzi, Antonella; Brizzi, Vittorio; Cascio, M. G.; Corelli, Federico; Guida, F.; Ligresti, A.; Maione, S.; Martinelli, A; Pasquini, S.; Tuccinardi, T.; Di Marzo, V.
Rapid combinatorial access to a library of 1,5-disubstituted-3-indole-N-alkylacetamides as CB2 receptor ligands
2009-01-01 Pasquini, Serena; Mugnaini, Claudia; Brizzi, Antonella; A., Ligresti; V., DI MARZO; C., Ghiron; Corelli, Federico
Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile.
2009-01-01 Silvestri, R.; Ligresti, A.; LA REGINA, G.; Piscitelli, F.; Gatti, V.; Brizzi, Antonella; Pasquini, Serena; Lavecchia, A.; Allarà, M.; Fantini, N.; Carai, M. A. M.; Novellino, E.; Colombo, G.; Di Marzo, V. D.; Corelli, Federico
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| Characterization of COR627 and COR628, two novel positive allosteric modulators of the GABA B receptor | 1-gen-2012 | Castelli, M. P.; Casu, A.; Casti, P.; Lobina, C.; Carai, M. A. M.; Colombo, G.; Solinas, M.; Giunta, D.; Mugnaini, Claudia; Pasquini, Serena; Tafi, Andrea; Brogi, Simone; Gessa, G. L.; Corelli, Federico | - | |
| The bioisosteric concept applied to cannabinoid ligands | 1-gen-2012 | Mugnaini, Claudia; Pasquini, Serena; Corelli, Federico | - | |
| Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach. | 1-gen-2012 | Mugnaini, Claudia; Nocerino, S.; Pedani, Valentina; Pasquini, Serena; Tafi, Andrea; De Chiaro, M.; Bellucci, L.; Valoti, Massimo; Guida, F.; Luongo, L.; Dragoni, Stefania; Ligresti, A.; Rosenberg, A.; Bolognini, D.; Cascio, M. G.; Pertwee, R. G.; Moaddel, R.; Maione, S.; Di Marzo, V.; Corelli, Federico | - | |
| Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 6. Synthesis and Pharmacological Evaluation of 7-Substituted 4-Quinolone-3-carboxamide Derivatives as High Affinity Ligands for Cannabinoid Receptors | 1-gen-2012 | Pasquini, Serena; DE ROSA, Maria; Ligresti, A.; Mugnaini, Claudia; Brizzi, Antonella; Caradonna, N. P.; Cascio, M. G.; Bolognini, D.; Pertwee, R. G.; Di Marzo, V.; Corelli, Federico | - | |
| Design, Synthesis, and Pharmacological Characterization of Indole-3-ylacetamides, Indole-3-yloxoacetamides, and Indole-3-ylcarboxamides: Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists | 1-gen-2012 | Pasquini, Serena; Mugnaini, Claudia; Ligresti, A.; Tafi, Andrea; Brogi, Simone; Falciani, C.; Pedani, Valentina; Pesco, N.; Guida, F.; Luongo, L.; Varani, K.; Borea, P. A.; Maione, S.; Di Marzo, V.; Corelli, Federico | - | |
| A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury | 1-gen-2012 | Contartese, Antonella; Valoti, Massimo; Corelli, Federico; Pasquini, Serena; Mugnaini, Claudia; Pessina, Federica; Aldinucci, Carlo; Sgaragli, GIAN PIETRO; Frosini, Maria | - | |
| Comparison of the effect of the positive allosteric modulator of the GABAb receptor, GS39783, on alcohol self-administration in three different lines of alcohol-preferring rats | 1-gen-2012 | Maccioni, P.; Zaru, A.; Loi, B.; Lobina, C.; Carai, M. A. M.; Gessa, G. L.; Capra, A.; Mugnaini, Claudia; Pasquini, Serena; Corelli, Federico; Hyytiä, P.; Lumeng, L.; Colombo, G. | - | |
| 1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: An effective scaffold for the design of either CB1 and CB2 receptor ligands | 1-gen-2011 | Piscitelli, F; Ligresti, A; LA REGINA, G; Gatti, V; Brizzi, Antonella; Pasquini, Serena; Allarà, M; CARAI M. A., M; Novellino, E; Colombo, G; DI MARZO, V; Corelli, Federico; Silvestri, R. | - | |
| Three-Dimensional Quantitative Structure-Selectivity Relationships (3D-QSSR) Analysis Guided Rational Design of a Highly Selective Ligand for the Cannabinoid Receptor 2 | 1-gen-2011 | Brogi, Simone; Corelli, Federico; V., DI MARZO; A., Ligresti; Mugnaini, Claudia; Pasquini, Serena; Tafi, Andrea | - | |
| Activation of the GABAB receptor prevents nicotine-induced locomotor stimulation in mice | 1-gen-2011 | Lobina, C.; Carai, M. A. M.; Froestl, W.; Mugnaini, Claudia; Pasquini, Serena; Corelli, Federico; G. e. s. s. a. G., L.; Colombo, G. | - | |
| Regioselective functionalization of quinolin-4(1H)-ones via sequential palladium-catalyzed reactions | 1-gen-2011 | Mugnaini, Claudia; Falciani, Chiara; DE ROSA, Maria; Brizzi, Antonella; Pasquini, Serena; Corelli, Federico | - | |
| Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 4. Identification of New Potent and Selective Ligands for the Cannabinoid Type 2 Receptor with Diverse Substitution Patterns and Antihyperalgesic Effects in Mice. | 1-gen-2011 | Pasquini, Serena; DE ROSA, Maria; Pedani, Valentina; Mugnaini, Claudia; Guida, F; Luongo, L; DE CHIARO, M; Maione, S; Dragoni, Stefania; Frosini, Maria; Ligresti, A; DI MARZO, V; Corelli, Federico | - | |
| Synthesis and biological evaluation of New N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands | 1-gen-2010 | Romano, Silvestri; Alessia, Ligresti; GIUSEPPE LA, Regina; Francesco, Piscitelli; Valerio, Gatti; Antonio, Lavecchia; Pasquini, Serena; Marco, Allarà; Noemi, Fantini; MAURO ANTONIO MARIA, Carai; Chiara, Bigogno; MARCO GIULIO, Rozio; Roberta, Sinisi; Ettore, Novellino; Giancarlo, Colombo; VINCENZO DI, Marzo; Giulio, Dondio; Brizzi, Antonella; Corelli, Federico | - | |
| In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB2 receptor inverse agonists | 1-gen-2010 | M. G., Cascio; D., Bolognini; R. G., Pertwee; E., Palazzo; Corelli, Federico; Pasquini, Serena; V., DI MARZO; S., Maione | - | |
| Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 3. Synthesis, Structure-Affinity Relationships, and Pharmacological Characterization of 6-Substituted 4-Quinolone-3-carboxamides as Highly Selective Cannabinoid-2 Receptor Ligands | 1-gen-2010 | Pasquini, Serena; Ligresti, A; Mugnaini, Claudia; Semeraro, Teresa; Cicione, L; DE ROSA, Maria; Guida, F; Luongo, L; DE CHIARO, M; CASCIO M., G; Bolognini, D; Marini, P; Pertwee, R; Maione, S; DI MARZO, V; Corelli, Federico | - | |
| Reduction by the positive allosteric modulator of the GABAB receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure | 1-gen-2010 | Maccioni, P; Flore, P; Carai, M. A. M.; Mugnaini, Claudia; Pasquini, Serena; Corelli, Federico; Gessa, G. L.; Colombo, G. | - | |
| The 4-Quinolone-3-carboxylic Acid Motif as a Multivalent Scaffold in Medicinal Chemistry | 1-gen-2009 | Mugnaini, Claudia; Pasquini, Serena; Corelli, Federico | - | |
| New Resorcinol-Anandamide "Hybrids" as Potent Cannabinoid Receptor Ligands Endowed with antinociceptive activity in vivo | 1-gen-2009 | Brizzi, Antonella; Brizzi, Vittorio; Cascio, M. G.; Corelli, Federico; Guida, F.; Ligresti, A.; Maione, S.; Martinelli, A; Pasquini, S.; Tuccinardi, T.; Di Marzo, V. | - | |
| Rapid combinatorial access to a library of 1,5-disubstituted-3-indole-N-alkylacetamides as CB2 receptor ligands | 1-gen-2009 | Pasquini, Serena; Mugnaini, Claudia; Brizzi, Antonella; A., Ligresti; V., DI MARZO; C., Ghiron; Corelli, Federico | - | |
| Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile. | 1-gen-2009 | Silvestri, R.; Ligresti, A.; LA REGINA, G.; Piscitelli, F.; Gatti, V.; Brizzi, Antonella; Pasquini, Serena; Lavecchia, A.; Allarà, M.; Fantini, N.; Carai, M. A. M.; Novellino, E.; Colombo, G.; Di Marzo, V. D.; Corelli, Federico | - |
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