Sfoglia per Autore
Development of Quinazolinone Derivatives as Modulators of Virulence Factors of Pseudomonas aeruginosa Cystic Fibrosis Strains
2023-01-01 Carullo, Gabriele; Di Bonaventura, Giovanni; Rossi, Sara; Lupetti, Veronica; Tudino, Valeria; Brogi, Simone; Butini, Stefania; Campiani, Giuseppe; Gemma, Sandra; Pompilio, Arianna
Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties
2022-01-01 Saletti, Mario; Maramai, Samuele; Reale, Annalisa; Paolino, Marco; Brogi, Simone; Di Capua, Angela; Cappelli, Andrea; Giorgi, Gianluca; D'Avino, Danilo; Rossi, Antonietta; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Sardella, Roccaldo; Carotti, Andrea; Woelkart, Gerald; Klösch, Burkhard; Bigogno, Chiara; Dondio, Giulio; Anzini, Maurizio
Synthesis of Unsymmetrical Squaramides as Allosteric GSK-3β Inhibitors Promoting β-Catenin-Mediated Transcription of TCF/LEF in Retinal Pigment Epithelial Cells
2022-01-01 Carullo, Gabriele; Bottoni, Laura; Pasquini, Silvia; Papa, Alessandro; Contri, Chiara; Brogi, Simone; Calderone, Vincenzo; Orlandini, Maurizio; Gemma, Sandra; Varani, Katia; Butini, Stefania; Galvagni, Federico; Vincenzi, Fabrizio; Campiani, Giuseppe
Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors
2022-01-01 Saccoccia, Fulvio; Pozzetti, Luca; Gimmelli, Roberto; Butini, Stefania; Guidi, Alessandra; Papoff, Giuliana; Giannaccari, Marialaura; Brogi, Simone; Scognamiglio, Viviana; Gemma, Sandra; Ruberti, Giovina; Campiani, Giuseppe
Optimization of Potent and Specific Trypanothione Reductase Inhibitors: A Structure-Based Drug Discovery Approach
2022-01-01 Battista, Theo; Federico, Stefano; Brogi, Simone; Pozzetti, Luca; Khan, Tuhina; Butini, Stefania; Ramunno, Anna; Fiorentino, Eleonora; Orsini, Stefania; Di Muccio, Trentina; Fiorillo, Annarita; Exertier, Cécile; Di Risola, Daniel; Colotti, Gianni; Gemma, Sandra; Ilari, Andrea; Campiani, Giuseppe
Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials
2020-01-01 Relitti, Nicola; Saraswati, Akella P; Federico, Stefano; Khan, Tuhina; Brindisi, Margherita; Zisterer, Daniela; Brogi, Simone; Gemma, Sandra; Butini, Stefania; Campiani, Giuseppe
Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions
2020-01-01 Frydenvang, Karla; Pickering, Darryl S; Kshirsagar, Giridhar U; Chemi, Giulia; Gemma, Sandra; Sprogøe, Desiree; Kærn, Anne Mette; Brogi, Simone; Campiani, Giuseppe; Butini, Stefania; Kastrup, Jette Sandholm
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases
2020-01-01 Brindisi, Margherita; Saraswati, A Prasanth; Brogi, Simone; Gemma, Sandra; Butini, Stefania; Campiani, Giuseppe
Computer-driven development of an in silico tool for finding selective histone deacetylase 1 inhibitors
2020-01-01 Sirous, H.; Campiani, G.; Brogi, S.; Calderone, V.; Chemi, G.
Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents
2020-01-01 Saccoccia, F.; Brindisi, M.; Gimmelli, R.; Relitti, N.; Guidi, A.; Saraswati, A. P.; Cavella, C.; Brogi, S.; Chemi, G.; Butini, S.; Papoff, G.; Senger, J.; Herp, D.; Jung, M.; Campiani, G.; Gemma, S.; Ruberti, G.
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation
2020-01-01 Saraswati, A Prasanth; Relitti, Nicola; Brindisi, Margherita; Osko, Jeremy D; Chemi, Giulia; Federico, Stefano; Grillo, Alessandro; Brogi, Simone; Mccabe, Niamh H; Turkington, Richard C; Ibrahim, Ola; O'Sullivan, Jeffrey; Lamponi, Stefania; Ghanim, Magda; Kelly, Vincent P; Zisterer, Daniela; Amet, Rebecca; Hannon Barroeta, Patricia; Vanni, Francesca; Ulivieri, Cristina; Herp, Daniel; Sarno, Federica; Di Costanzo, Antonella; Saccoccia, Fulvio; Ruberti, Giovina; Jung, Manfred; Altucci, Lucia; Gemma, Sandra; Butini, Stefania; Christianson, David W; Campiani, Giuseppe
Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach
2019-01-01 Sirous, Hajar; Chemi, Giulia; Gemma, Sandra; Butini, Stefania; Debyser, Zeger; Christ, Frauke; Saghaie, Lotfollah; Brogi, Simone; Fassihi, Afshin; Campiani, Giuseppe; Brindisi, Margherita
A repurposing approach for uncovering the anti-tubercular activity of FDA-approved drugs with Potential Multi-Targeting Profiles
2019-01-01 Battah, B.; Chemi, G.; Butini, S.; Campiani, G.; Brogi, S.; Delogu, G.; Gemma, S.
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders
2019-01-01 Brogi, Simone; Campiani, Giuseppe; Brindisi, Margherita; Butini, Stefania
Dietary polyphenols rutin, taxifolin and quercetin related compounds target: Leishmania amazonensis arginase
2019-01-01 Da Silva, E. R.; Brogi, S.; Lucon-Junior, J. F.; Campiani, G.; Gemma, S.; Maquiaveli, C. D. C.
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II)
2019-01-01 D'Alessandro, S.; Alfano, G.; Di Cerbo, L.; Brogi, S.; Chemi, G.; Relitti, N.; Brindisi, M.; Lamponi, S.; Novellino, E.; Campiani, G.; Gemma, S.; Basilico, N.; Taramelli, D.; Baratto, M. C.; Pogni, R.; Butini, S.
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision
2019-01-01 Chemi, G.; Brindisi, M.; Brogi, S.; Relitti, N.; Butini, S.; Gemma, S.; Campiani, G.
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors
2019-01-01 Sirous, Hajar; Fassihi, Afshin; Brogi, Simone; Campiani, Giuseppe; Christ, Frauke; Debyser, Zeger; Gemma, Sandra; Butini, Stefania; Chemi, Giulia; Grillo, Alessandro; Zabihollahi, Rezvan; Aghasadeghi, Mohammad R; Saghaie, Lotfollah; Memarian, Hamid R
Cinnamic acids derived compounds with antileishmanial activity target Leishmania amazonensis arginase
2019-01-01 da Silva, Edson Roberto; Brogi, Simone; Grillo, Alessandro; Campiani, Giuseppe; Gemma, Sandra; Vieira, Paulo Cezar; Maquiaveli, Claudia do Carmo
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues
2018-01-01 Vallone, Alessandra; D'Alessandro, Sarah; Brogi, Simone; Brindisi, Margherita; Chemi, Giulia; Alfano, Gloria; Lamponi, Stefania; Lee, Soon Goo; Jez, Joseph M.; Koolen, Karin J. M.; Dechering, Koen J.; Saponara, Simona; Fusi, Fabio; Gorelli, Beatrice; Taramelli, Donatella; Parapini, Silvia; Caldelari, Reto; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| Development of Quinazolinone Derivatives as Modulators of Virulence Factors of Pseudomonas aeruginosa Cystic Fibrosis Strains | 1-gen-2023 | Carullo, Gabriele; Di Bonaventura, Giovanni; Rossi, Sara; Lupetti, Veronica; Tudino, Valeria; Brogi, Simone; Butini, Stefania; Campiani, Giuseppe; Gemma, Sandra; Pompilio, Arianna | - | |
| Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties | 1-gen-2022 | Saletti, Mario; Maramai, Samuele; Reale, Annalisa; Paolino, Marco; Brogi, Simone; Di Capua, Angela; Cappelli, Andrea; Giorgi, Gianluca; D'Avino, Danilo; Rossi, Antonietta; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Sardella, Roccaldo; Carotti, Andrea; Woelkart, Gerald; Klösch, Burkhard; Bigogno, Chiara; Dondio, Giulio; Anzini, Maurizio | - | |
| Synthesis of Unsymmetrical Squaramides as Allosteric GSK-3β Inhibitors Promoting β-Catenin-Mediated Transcription of TCF/LEF in Retinal Pigment Epithelial Cells | 1-gen-2022 | Carullo, Gabriele; Bottoni, Laura; Pasquini, Silvia; Papa, Alessandro; Contri, Chiara; Brogi, Simone; Calderone, Vincenzo; Orlandini, Maurizio; Gemma, Sandra; Varani, Katia; Butini, Stefania; Galvagni, Federico; Vincenzi, Fabrizio; Campiani, Giuseppe | - | |
| Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors | 1-gen-2022 | Saccoccia, Fulvio; Pozzetti, Luca; Gimmelli, Roberto; Butini, Stefania; Guidi, Alessandra; Papoff, Giuliana; Giannaccari, Marialaura; Brogi, Simone; Scognamiglio, Viviana; Gemma, Sandra; Ruberti, Giovina; Campiani, Giuseppe | - | |
| Optimization of Potent and Specific Trypanothione Reductase Inhibitors: A Structure-Based Drug Discovery Approach | 1-gen-2022 | Battista, Theo; Federico, Stefano; Brogi, Simone; Pozzetti, Luca; Khan, Tuhina; Butini, Stefania; Ramunno, Anna; Fiorentino, Eleonora; Orsini, Stefania; Di Muccio, Trentina; Fiorillo, Annarita; Exertier, Cécile; Di Risola, Daniel; Colotti, Gianni; Gemma, Sandra; Ilari, Andrea; Campiani, Giuseppe | - | |
| Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials | 1-gen-2020 | Relitti, Nicola; Saraswati, Akella P; Federico, Stefano; Khan, Tuhina; Brindisi, Margherita; Zisterer, Daniela; Brogi, Simone; Gemma, Sandra; Butini, Stefania; Campiani, Giuseppe | - | |
| Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions | 1-gen-2020 | Frydenvang, Karla; Pickering, Darryl S; Kshirsagar, Giridhar U; Chemi, Giulia; Gemma, Sandra; Sprogøe, Desiree; Kærn, Anne Mette; Brogi, Simone; Campiani, Giuseppe; Butini, Stefania; Kastrup, Jette Sandholm | - | |
| Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases | 1-gen-2020 | Brindisi, Margherita; Saraswati, A Prasanth; Brogi, Simone; Gemma, Sandra; Butini, Stefania; Campiani, Giuseppe | - | |
| Computer-driven development of an in silico tool for finding selective histone deacetylase 1 inhibitors | 1-gen-2020 | Sirous, H.; Campiani, G.; Brogi, S.; Calderone, V.; Chemi, G. | - | |
| Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents | 1-gen-2020 | Saccoccia, F.; Brindisi, M.; Gimmelli, R.; Relitti, N.; Guidi, A.; Saraswati, A. P.; Cavella, C.; Brogi, S.; Chemi, G.; Butini, S.; Papoff, G.; Senger, J.; Herp, D.; Jung, M.; Campiani, G.; Gemma, S.; Ruberti, G. | - | |
| Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation | 1-gen-2020 | Saraswati, A Prasanth; Relitti, Nicola; Brindisi, Margherita; Osko, Jeremy D; Chemi, Giulia; Federico, Stefano; Grillo, Alessandro; Brogi, Simone; Mccabe, Niamh H; Turkington, Richard C; Ibrahim, Ola; O'Sullivan, Jeffrey; Lamponi, Stefania; Ghanim, Magda; Kelly, Vincent P; Zisterer, Daniela; Amet, Rebecca; Hannon Barroeta, Patricia; Vanni, Francesca; Ulivieri, Cristina; Herp, Daniel; Sarno, Federica; Di Costanzo, Antonella; Saccoccia, Fulvio; Ruberti, Giovina; Jung, Manfred; Altucci, Lucia; Gemma, Sandra; Butini, Stefania; Christianson, David W; Campiani, Giuseppe | - | |
| Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach | 1-gen-2019 | Sirous, Hajar; Chemi, Giulia; Gemma, Sandra; Butini, Stefania; Debyser, Zeger; Christ, Frauke; Saghaie, Lotfollah; Brogi, Simone; Fassihi, Afshin; Campiani, Giuseppe; Brindisi, Margherita | - | |
| A repurposing approach for uncovering the anti-tubercular activity of FDA-approved drugs with Potential Multi-Targeting Profiles | 1-gen-2019 | Battah, B.; Chemi, G.; Butini, S.; Campiani, G.; Brogi, S.; Delogu, G.; Gemma, S. | - | |
| Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders | 1-gen-2019 | Brogi, Simone; Campiani, Giuseppe; Brindisi, Margherita; Butini, Stefania | - | |
| Dietary polyphenols rutin, taxifolin and quercetin related compounds target: Leishmania amazonensis arginase | 1-gen-2019 | Da Silva, E. R.; Brogi, S.; Lucon-Junior, J. F.; Campiani, G.; Gemma, S.; Maquiaveli, C. D. C. | - | |
| Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) | 1-gen-2019 | D'Alessandro, S.; Alfano, G.; Di Cerbo, L.; Brogi, S.; Chemi, G.; Relitti, N.; Brindisi, M.; Lamponi, S.; Novellino, E.; Campiani, G.; Gemma, S.; Basilico, N.; Taramelli, D.; Baratto, M. C.; Pogni, R.; Butini, S. | - | |
| A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision | 1-gen-2019 | Chemi, G.; Brindisi, M.; Brogi, S.; Relitti, N.; Butini, S.; Gemma, S.; Campiani, G. | - | |
| Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors | 1-gen-2019 | Sirous, Hajar; Fassihi, Afshin; Brogi, Simone; Campiani, Giuseppe; Christ, Frauke; Debyser, Zeger; Gemma, Sandra; Butini, Stefania; Chemi, Giulia; Grillo, Alessandro; Zabihollahi, Rezvan; Aghasadeghi, Mohammad R; Saghaie, Lotfollah; Memarian, Hamid R | - | |
| Cinnamic acids derived compounds with antileishmanial activity target Leishmania amazonensis arginase | 1-gen-2019 | da Silva, Edson Roberto; Brogi, Simone; Grillo, Alessandro; Campiani, Giuseppe; Gemma, Sandra; Vieira, Paulo Cezar; Maquiaveli, Claudia do Carmo | - | |
| Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues | 1-gen-2018 | Vallone, Alessandra; D'Alessandro, Sarah; Brogi, Simone; Brindisi, Margherita; Chemi, Giulia; Alfano, Gloria; Lamponi, Stefania; Lee, Soon Goo; Jez, Joseph M.; Koolen, Karin J. M.; Dechering, Koen J.; Saponara, Simona; Fusi, Fabio; Gorelli, Beatrice; Taramelli, Donatella; Parapini, Silvia; Caldelari, Reto; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania | - |
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