Sfoglia per Autore
Wine Lees as Source of Antioxidant Molecules: Green Extraction Procedure and Biological Activity
2023-01-01 Luca Michele, De; Restuccia, Donatella; Gianfranco Spizzirri, Umile; Crupi, Pasquale; Ioele, Giuseppina; Gorelli, Beatrice; Lisa Clodoveo, Maria; Saponara, Simona; Aiello, Francesca
Off-label use of hydroxychloroquine in COVID-19: analysis of reports of suspected adverse reactions from the Italian National Network of Pharmacovigilance
2022-01-01 Fallani, E.; Cevenini, F.; Lazzerini, P. E.; Verdini, A.; Saponara, S.
Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature
2022-01-01 Trezza, A.; Spiga, O.; Mugnai, P.; Saponara, S.; Sgaragli, G.; Fusi, F.
Nitrobenzoxadiazole derivatives of the rat selective toxicant norbormide as fluorescent probes for live cell imaging
2022-01-01 Wang, Z. L.; Li, F. F.; Quach, R.; Ferrarese, A.; Forgiarini, A.; Ferrari, M.; D'Amore, C.; Bova, S.; Orso, G.; Fusi, F.; Saponara, S.; Hopkins, B.; Brimble, M. A.; Rennison, D.
Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators
2022-01-01 Cuong, Nguyen Manh; Son, Ninh The; Nhan, Ngu Truong; Fukuyama, Yoshiyasu; Ahmed, Amer; Saponara, Simona; Trezza, Alfonso; Gianibbi, Beatrice; Vigni, Ginevra; Spiga, Ottavia; Fusi, Fabio
Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions
2022-01-01 Papa, Alessandro; Pasquini, Silvia; Galvani, Francesca; Cammarota, Mariarosaria; Contri, Chiara; Carullo, Gabriele; Gemma, Sandra; Ramunno, Anna; Lamponi, Stefania; Gorelli, Beatrice; Saponara, Simona; Varani, Katia; Mor, Marco; Campiani, Giuseppe; Boscia, Francesca; Vincenzi, Fabrizio; Lodola, Alessio; Butini, Stefania
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability
2022-01-01 Federico, S.; Khan, T.; Fontana, A.; Brogi, S.; Benedetti, R.; Sarno, F.; Carullo, G.; Pezzotta, A.; Saraswati, A. P.; Passaro, E.; Pozzetti, L.; Papa, A.; Relitti, N.; Gemma, S.; Butini, S.; Pistocchi, A.; Ramunno, A.; Vincenzi, F.; Varani, K.; Tatangelo, V.; Patrussi, L.; Baldari, C. T.; Saponara, S.; Gorelli, B.; Lamponi, S.; Valoti, M.; Saccoccia, F.; Giannaccari, M.; Ruberti, G.; Herp, D.; Jung, M.; Altucci, L.; Campiani, G.
Artificial intelligence-driven identification of morin analogues acting as CaV1.2 channel blockers: Synthesis and biological evaluation
2022-01-01 Carullo, G.; Falbo, F.; Ahmed, A.; Trezza, A.; Gianibbi, B.; Nicolotti, O.; Campiani, G.; Aiello, F.; Saponara, S.; Fusi, F.
A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors
2022-01-01 Alov, Petko; Al Sharif, Merilin; Aluani, Denitsa; Chegaev, Konstantin; Dinic, Jelena; Divac Rankov, Aleksandra; Fernandes, Miguel X; Fusi, Fabio; García-Sosa, Alfonso T; Juvonen, Risto; Kondeva-Burdina, Magdalena; Padrón, José M; Pajeva, Ilza; Pencheva, Tania; Puerta, Adrián; Raunio, Hannu; Riganti, Chiara; Tsakovska, Ivanka; Tzankova, Virginia; Yordanov, Yordan; Saponara, Simona
Sdox, a H2S releasing anthracycline, with a safer profile than doxorubicin toward vasculature
2022-01-01 Durante, M.; Frosini, M.; Chiaino, E.; Fusi, F.; Gamberucci, A.; Gorelli, B.; Chegaev, K.; Riganti, C.; Saponara, S.
Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels
2022-01-01 Carullo, Gabriele; Saponara, Simona; Ahmed, Amer; Gorelli, Beatrice; Mazzotta, Sarah; Trezza, Alfonso; Gianibbi, Beatrice; Campiani, Giuseppe; Fusi, Fabio; Aiello, Francesca
A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels
2021-01-01 Carullo, G.; Ahmed, A.; Trezza, A.; Spiga, O.; Brizzi, A.; Saponara, S.; Fusi, F.; Aiello, F.
Hypoxia as a driver of resistance to immunotherapy
2021-01-01 Kopecka, J.; Salaroglio, I. C.; Perez-Ruiz, E.; Sarmento-Ribeiro, A. B.; Saponara, S.; De Las Rivas, J.; Riganti, C.
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents
2021-01-01 Grillo, Alessandro; Fezza, Filomena; Chemi, Giulia; Colangeli, Roberto; Brogi, Simone; Fazio, Domenico; Federico, Stefano; Papa, Alessandro; Relitti, Nicola; Di Maio, Roberto; Giorgi, Gianluca; Lamponi, Stefania; Valoti, Massimo; Gorelli, Beatrice; Saponara, Simona; Benedusi, Mascia; Pecorelli, Alessandra; Minetti, Patrizia; Valacchi, Giuseppe; Butini, Stefania; Campiani, Giuseppe; Gemma, Sandra; Maccarrone, Mauro; Di Giovanni, Giuseppe
2-hydroxy-4-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation
2021-01-01 Brizzi, A.; Trezza, A.; Spiga, O.; Maramai, S.; Scorzelli, F.; Saponara, S.; Fusi, F.
Proton pump inhibitors directly block hERG-potassium channel and independently increase the risk of QTc prolongation in a large cohort of US Veterans
2021-01-01 Lazzerini, P. E.; Cartocci, A.; Qu, Y. S.; Saponara, S.; Furini, S.; Fusi, F.; Fabris, F.; Gamberucci, A.; El-Sherif, N.; Cevenini, G.; Pettini, F.; Laghi-Pasini, F.; Acampa, M.; Bertolozzi, I.; Capecchi, P. L.; Lazaro, D.; Boutjdir, M.
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors
2021-01-01 Campiani, Giuseppe; Cavella, Caterina; Osko, Jeremy D; Brindisi, Margherita; Relitti, Nicola; Brogi, Simone; Saraswati, A Prasanth; Federico, Stefano; Chemi, Giulia; Maramai, Samuele; Carullo, Gabriele; Jaeger, Benedikt; Carleo, Alfonso; Benedetti, Rosaria; Sarno, Federica; Lamponi, Stefania; Rottoli, Paola; Bargagli, Elena; Bertucci, Carlo; Tedesco, Daniele; Herp, Daniel; Senger, Johanna; Ruberti, Giovina; Saccoccia, Fulvio; Saponara, Simona; Gorelli, Beatrice; Valoti, Massimo; Kennedy, Breándan; Sundaramurthi, Husvinee; Butini, Stefania; Jung, Manfred; Roach, Katy M; Altucci, Lucia; Bradding, Peter; Christianson, David W; Gemma, Sandra; Prasse, Antje
Flavonoids and hERG channels: Friends or foes?
2021-01-01 Saponara, S.; Fusi, F.; Iovinelli, D.; Ahmed, A.; Trezza, A.; Spiga, O.; Sgaragli, G.; Valoti, M.
Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators
2020-01-01 Carullo, G.; Ahmed, A.; Trezza, A.; Spiga, O.; Brizzi, A.; Saponara, S.; Fusi, F.; Aiello, F.
In vitro vascular toxicity assessment of NitDOX, a novel NO-releasing doxorubicin
2020-01-01 Durante, M.; Frosini, M.; Fusi, F.; Gamberucci, A.; Chegaev, K.; Rolando, B.; Riganti, C.; Fruttero, R.; Saponara, S.
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| Wine Lees as Source of Antioxidant Molecules: Green Extraction Procedure and Biological Activity | 1-gen-2023 | Luca Michele, De; Restuccia, Donatella; Gianfranco Spizzirri, Umile; Crupi, Pasquale; Ioele, Giuseppina; Gorelli, Beatrice; Lisa Clodoveo, Maria; Saponara, Simona; Aiello, Francesca | - | |
| Off-label use of hydroxychloroquine in COVID-19: analysis of reports of suspected adverse reactions from the Italian National Network of Pharmacovigilance | 1-gen-2022 | Fallani, E.; Cevenini, F.; Lazzerini, P. E.; Verdini, A.; Saponara, S. | - | |
| Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature | 1-gen-2022 | Trezza, A.; Spiga, O.; Mugnai, P.; Saponara, S.; Sgaragli, G.; Fusi, F. | - | |
| Nitrobenzoxadiazole derivatives of the rat selective toxicant norbormide as fluorescent probes for live cell imaging | 1-gen-2022 | Wang, Z. L.; Li, F. F.; Quach, R.; Ferrarese, A.; Forgiarini, A.; Ferrari, M.; D'Amore, C.; Bova, S.; Orso, G.; Fusi, F.; Saponara, S.; Hopkins, B.; Brimble, M. A.; Rennison, D. | - | |
| Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators | 1-gen-2022 | Cuong, Nguyen Manh; Son, Ninh The; Nhan, Ngu Truong; Fukuyama, Yoshiyasu; Ahmed, Amer; Saponara, Simona; Trezza, Alfonso; Gianibbi, Beatrice; Vigni, Ginevra; Spiga, Ottavia; Fusi, Fabio | - | |
| Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions | 1-gen-2022 | Papa, Alessandro; Pasquini, Silvia; Galvani, Francesca; Cammarota, Mariarosaria; Contri, Chiara; Carullo, Gabriele; Gemma, Sandra; Ramunno, Anna; Lamponi, Stefania; Gorelli, Beatrice; Saponara, Simona; Varani, Katia; Mor, Marco; Campiani, Giuseppe; Boscia, Francesca; Vincenzi, Fabrizio; Lodola, Alessio; Butini, Stefania | - | |
| Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability | 1-gen-2022 | Federico, S.; Khan, T.; Fontana, A.; Brogi, S.; Benedetti, R.; Sarno, F.; Carullo, G.; Pezzotta, A.; Saraswati, A. P.; Passaro, E.; Pozzetti, L.; Papa, A.; Relitti, N.; Gemma, S.; Butini, S.; Pistocchi, A.; Ramunno, A.; Vincenzi, F.; Varani, K.; Tatangelo, V.; Patrussi, L.; Baldari, C. T.; Saponara, S.; Gorelli, B.; Lamponi, S.; Valoti, M.; Saccoccia, F.; Giannaccari, M.; Ruberti, G.; Herp, D.; Jung, M.; Altucci, L.; Campiani, G. | - | |
| Artificial intelligence-driven identification of morin analogues acting as CaV1.2 channel blockers: Synthesis and biological evaluation | 1-gen-2022 | Carullo, G.; Falbo, F.; Ahmed, A.; Trezza, A.; Gianibbi, B.; Nicolotti, O.; Campiani, G.; Aiello, F.; Saponara, S.; Fusi, F. | - | |
| A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors | 1-gen-2022 | Alov, Petko; Al Sharif, Merilin; Aluani, Denitsa; Chegaev, Konstantin; Dinic, Jelena; Divac Rankov, Aleksandra; Fernandes, Miguel X; Fusi, Fabio; García-Sosa, Alfonso T; Juvonen, Risto; Kondeva-Burdina, Magdalena; Padrón, José M; Pajeva, Ilza; Pencheva, Tania; Puerta, Adrián; Raunio, Hannu; Riganti, Chiara; Tsakovska, Ivanka; Tzankova, Virginia; Yordanov, Yordan; Saponara, Simona | - | |
| Sdox, a H2S releasing anthracycline, with a safer profile than doxorubicin toward vasculature | 1-gen-2022 | Durante, M.; Frosini, M.; Chiaino, E.; Fusi, F.; Gamberucci, A.; Gorelli, B.; Chegaev, K.; Riganti, C.; Saponara, S. | - | |
| Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels | 1-gen-2022 | Carullo, Gabriele; Saponara, Simona; Ahmed, Amer; Gorelli, Beatrice; Mazzotta, Sarah; Trezza, Alfonso; Gianibbi, Beatrice; Campiani, Giuseppe; Fusi, Fabio; Aiello, Francesca | - | |
| A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels | 1-gen-2021 | Carullo, G.; Ahmed, A.; Trezza, A.; Spiga, O.; Brizzi, A.; Saponara, S.; Fusi, F.; Aiello, F. | - | |
| Hypoxia as a driver of resistance to immunotherapy | 1-gen-2021 | Kopecka, J.; Salaroglio, I. C.; Perez-Ruiz, E.; Sarmento-Ribeiro, A. B.; Saponara, S.; De Las Rivas, J.; Riganti, C. | - | |
| Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents | 1-gen-2021 | Grillo, Alessandro; Fezza, Filomena; Chemi, Giulia; Colangeli, Roberto; Brogi, Simone; Fazio, Domenico; Federico, Stefano; Papa, Alessandro; Relitti, Nicola; Di Maio, Roberto; Giorgi, Gianluca; Lamponi, Stefania; Valoti, Massimo; Gorelli, Beatrice; Saponara, Simona; Benedusi, Mascia; Pecorelli, Alessandra; Minetti, Patrizia; Valacchi, Giuseppe; Butini, Stefania; Campiani, Giuseppe; Gemma, Sandra; Maccarrone, Mauro; Di Giovanni, Giuseppe | - | |
| 2-hydroxy-4-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation | 1-gen-2021 | Brizzi, A.; Trezza, A.; Spiga, O.; Maramai, S.; Scorzelli, F.; Saponara, S.; Fusi, F. | - | |
| Proton pump inhibitors directly block hERG-potassium channel and independently increase the risk of QTc prolongation in a large cohort of US Veterans | 1-gen-2021 | Lazzerini, P. E.; Cartocci, A.; Qu, Y. S.; Saponara, S.; Furini, S.; Fusi, F.; Fabris, F.; Gamberucci, A.; El-Sherif, N.; Cevenini, G.; Pettini, F.; Laghi-Pasini, F.; Acampa, M.; Bertolozzi, I.; Capecchi, P. L.; Lazaro, D.; Boutjdir, M. | - | |
| Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors | 1-gen-2021 | Campiani, Giuseppe; Cavella, Caterina; Osko, Jeremy D; Brindisi, Margherita; Relitti, Nicola; Brogi, Simone; Saraswati, A Prasanth; Federico, Stefano; Chemi, Giulia; Maramai, Samuele; Carullo, Gabriele; Jaeger, Benedikt; Carleo, Alfonso; Benedetti, Rosaria; Sarno, Federica; Lamponi, Stefania; Rottoli, Paola; Bargagli, Elena; Bertucci, Carlo; Tedesco, Daniele; Herp, Daniel; Senger, Johanna; Ruberti, Giovina; Saccoccia, Fulvio; Saponara, Simona; Gorelli, Beatrice; Valoti, Massimo; Kennedy, Breándan; Sundaramurthi, Husvinee; Butini, Stefania; Jung, Manfred; Roach, Katy M; Altucci, Lucia; Bradding, Peter; Christianson, David W; Gemma, Sandra; Prasse, Antje | - | |
| Flavonoids and hERG channels: Friends or foes? | 1-gen-2021 | Saponara, S.; Fusi, F.; Iovinelli, D.; Ahmed, A.; Trezza, A.; Spiga, O.; Sgaragli, G.; Valoti, M. | - | |
| Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators | 1-gen-2020 | Carullo, G.; Ahmed, A.; Trezza, A.; Spiga, O.; Brizzi, A.; Saponara, S.; Fusi, F.; Aiello, F. | - | |
| In vitro vascular toxicity assessment of NitDOX, a novel NO-releasing doxorubicin | 1-gen-2020 | Durante, M.; Frosini, M.; Fusi, F.; Gamberucci, A.; Chegaev, K.; Rolando, B.; Riganti, C.; Fruttero, R.; Saponara, S. | - |
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