Sfoglia per Autore NACCI, VITO
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships
2009-01-01 Morelli, Elena; Gemma, Sandra; Budriesi, Roberta; Campiani, Giuseppe; Novellino, Ettore; Fattorusso, Caterina; Catalanotti, Bruno; Coccone, Salvatore Sanna; Sindu, Ros; Borrelli, Giuseppe; Kumar, Vinod; Persico, Marco; Fiorini, Isabella; Nacci, Vito; Ioan, Pierfranco; Chiarini, Alberto; Hamon, Michel; Cagnotto, Alfredo; Mennini, Tiziana; Fracasso, Claudia; Colovic, Milena; Caccia, Silvio; Butini, Stefania
Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials
2009-01-01 Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Joshi, B. P.; Kukreja, G.; Sanna Coccone, Salvatore; Bernetti, Matteo; Persico, M.; Nacci, Vito; Fiorini, Isabella; Novellino, E.; Taramelli, D.; Basilico, N.; Parapini, S.; Yardley, V.; Croft, S.; Kellere Maerki, S.; Rottmann, M.; Brun, R.; Coletta, M.; Marini, S.; Guiso, G.; Caccia, S.; Fattorusso, C.
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior
2009-01-01 Butini, Stefania; Gemma, Sandra; Campiani, Giuseppe; Franceschini, Silvia; Trotta, Francesco; Borriello, Marianna; Ceres, Nicoletta; Sindu, Ros; Coccone, Salvatore Sanna; Bernetti, Matteo; De Angelis, Meri; Brindisi, Margherita; Nacci, Vito; Fiorini, Isabella; Novellino, Ettore; Cagnotto, Alfredo; Mennini, Tiziana; Sandager-Nielsen, Karin; Andreasen, Jesper Tobias; Scheel-Kruger, Jorgen; Mikkelsen, Jens D.; Fattorusso, Caterina
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors
2008-01-01 Butini, Stefania; Campiani, Giuseppe; Borriello, M.; Gemma, Sandra; Panico, Alessandro; Persico, M.; Catalanotti, B.; Ros, S.; Brindisi, Margherita; Agnusdei, M.; Fiorini, Isabella; Nacci, Vito; Novellino, E.; Belinskaya, T.; Saxena, A.; Fattorusso, C.
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies
2008-01-01 Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Kukreja, G.; Sanna Coccone, Salvatore; Joshi, B.; Persico, M.; Nacci, Vito; Fiorini, Isabella; Novellino, E.; Fattorusso, E; Taglialatela Scafati, O.; Savini, Luisa; Taramelli, D.; Basilico, N.; Parapini, S.; Morace, G.; Yardley, V.; Croft, S.; Coletta, M.; Marini, S.; Fattorusso, Caterina
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents
2008-01-01 Fattorusso, Caterina; Campiani, Giuseppe; Kukreja, Gagan; Persico, Marco; Butini, Stefania; Romano, Maria Pia; Altarelli, Maria; Sindu, Ros; Brindisi, Margherita; Savini, Luisa; Novellino, Ettore; Nacci, Vito; Fattorusso, Ernesto; Parapini, Silvia; Basilico, Nicoletta; Taramelli, Donatella; Yardley, Vanessa; Croft, Simon; Borriello, Marianna; Gemma, Sandra
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore
2007-01-01 Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Joshi, B.; Kukreja, G.; Persico, M.; Catalanotti, B.; Novellino, E.; Fattorusso, E; Nacci, Vito; Savini, Luisa; Taramelli, D.; Basilico, N.; Morace, G.; Yardley, V.; Fattorusso, C.
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites
2006-01-01 Gemma, Sandra; Gabellieri, Emanuele; Huleatt, P.; Fattorusso, C.; Borriello, M.; Catalanotti, B.; Butini, Stefania; De Angelis, M.; Novellino, E.; Nacci, Vito; Belinskaya, T.; Saxena, Ashima; Campiani, Giuseppe
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies
2005-01-01 Campiani, Giuseppe; Butini, Stefania; Fattorusso, Caterina; Frotta, Francesco; Gemma, Sandra; Catalanotti, Bruno; Nacci, Vito; Fiorini, Isabella; Cagnotto, Alfredo; Mereghetti, Ilario; Mennini, Tiziana; Minetti, Patrizia; Di Cesare, M. Assunta; Stasi, M. Antonietta; Di Serio, Stefano; Ghirardi, Orlando; Tinti, Ornella; Carminati, Paolo
The pyrrolo-1,5-benzoxazepine,PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumor growth in vivo
2005-01-01 Greene, Lisa M.; Fleeton, Marina; Mulligan, Jude; Gowda, Chikkanna; Sheahan, Brian J.; Atkins, Gregory J.; Campiani, Giuseppe; Nacci, Vito; Lawler, Mark; Williams, D. Clive; Zisterer, Daniela M.
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors
2005-01-01 Campiani, Giuseppe; Fattorusso, C; Butini, Stefania; Gaeta, A; Agnusdei, M; Gemma, Sandra; Persico, M; Catalanotti, B; Savini, Luisa; Nacci, Vito; Novellino, E; Holloway, Hw; Greig, Nh; Belinskaya, T; Fedorko, Jm; Saxena, A.
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663
2005-01-01 Maga, G.; Gemma, Sandra; Fattorusso, C.; Locatelli, G. A.; Butini, Stefania; Persico, M.; Kukreja, G.; Romano, M. P.; Chiasserini, Luisa; Savini, Luisa; Novellino, E.; Nacci, Vito; Spadari, S.; Campiani, Giuseppe
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target
2005-01-01 Mc Gee, M. M.; Gemma, Sandra; Butini, Stefania; Ramunno, A.; Zisterer, D. M.; Fattorusso, C.; Catalanotti, B.; Kukreja, G.; Fiorini, Isabella; Pisano, C.; Cucco, C.; Novellino, E.; Nacci, Vito; Williams, D. C.; Campiani, Giuseppe
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity
2005-01-01 Fattorusso, Caterina; Gemma, Sandra; Butini, Stefania; Huleatt, Paul; Catalanotti, Bruno; Persico, Marco; De Angelis, Meri; Fiorini, Isabella; Nacci, Vito; Ramunno, Anna; Rodriquez, Manuela; Greco, Giovanni; Novellino, Ettore; Bergamini, Alberto; Marini, Stefano; Coletta, Massimo; Maga, Giovanni; Spadari, Silvio; Campiani, Giuseppe
Pyrrolo[1,3]benzothiazepine-Based Serotonin and Dopamine Receptor Antagonists. Molecular Modeling, Further Structure-Activity Relationship Studies, and Identification of Novel Atypical Antipsychotic Agents
2004-01-01 Campiani, Giuseppe; Butini, Stefania; Fattorusso, C; Catalanotti, B; Gemma, Sandra; Nacci, Vito; Morelli, E; Cagnotto, A; Mereghetti, I; Mennini, T; Carli, M; Minetti, P; DI CESARE, M. A.; Mastroianni, D; Scafetta, N; Galletti, B; Stasi, M. A.; Castorina, M; Pacifici, L; Vertechy, M; Serio, S. D.; Ghirardi, O; Tinti, O; Carminati, P.
Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL
2004-01-01 Mc Gee, Margaret M.; Greene, Lisa M.; Ledwidge, Susan; Campiani, Giuseppe; Nacci, Vito; Lawler, Mark; Williams, D. Clive; Zisterer, Daniela M.
Neuronal high affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases
2003-01-01 Campiani, G.; Fattorusso, C.; DE ANGELIS, M.; Catalanotti, B.; Butini, S.; Fattorusso, R.; Fiorini, I.; Nacci, V.; Novellino, E.
Novel antipsychotic agents: recent advances in the drug treatment of schizophrenia
2003-01-01 Butini, Stefania; Campiani, Giuseppe; De Angelis, Meri; Fattorusso, Caterina; Nacci, Vito; Fiorini, Isabella
Synthesis and Pharmacological Evaluation of Potent and Highly Selective D3 Receptor Ligands: Inhibition of Cocaine-Seeking Behaviour and the Role of Dopamine D3/D2Receptors
2003-01-01 Campiani, G.; Butini, S.; Trotta, F.; Fattorusso, C.; Catalanotti, B.; Aiello, F.; Gemma, S.; Nacci, V.; Novellino, E.; Stark, J. A.; Cagnotto, A.; Fumagalli, E.; Carnovali, F.; Cervo, L.; Mennini, T.
Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human astrocytoma cells by the pyrrolo-1,5-benzoxazepine, PBOX-21
2003-01-01 Mulligan, Jude M.; Campiani, Giuseppe; Ramunno, Anna; Nacci, Vito; Zisterer, Daniela M.
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships | 1-gen-2009 | Morelli, Elena; Gemma, Sandra; Budriesi, Roberta; Campiani, Giuseppe; Novellino, Ettore; Fattorusso, Caterina; Catalanotti, Bruno; Coccone, Salvatore Sanna; Sindu, Ros; Borrelli, Giuseppe; Kumar, Vinod; Persico, Marco; Fiorini, Isabella; Nacci, Vito; Ioan, Pierfranco; Chiarini, Alberto; Hamon, Michel; Cagnotto, Alfredo; Mennini, Tiziana; Fracasso, Claudia; Colovic, Milena; Caccia, Silvio; Butini, Stefania | - | |
| Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials | 1-gen-2009 | Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Joshi, B. P.; Kukreja, G.; Sanna Coccone, Salvatore; Bernetti, Matteo; Persico, M.; Nacci, Vito; Fiorini, Isabella; Novellino, E.; Taramelli, D.; Basilico, N.; Parapini, S.; Yardley, V.; Croft, S.; Kellere Maerki, S.; Rottmann, M.; Brun, R.; Coletta, M.; Marini, S.; Guiso, G.; Caccia, S.; Fattorusso, C. | - | |
| Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior | 1-gen-2009 | Butini, Stefania; Gemma, Sandra; Campiani, Giuseppe; Franceschini, Silvia; Trotta, Francesco; Borriello, Marianna; Ceres, Nicoletta; Sindu, Ros; Coccone, Salvatore Sanna; Bernetti, Matteo; De Angelis, Meri; Brindisi, Margherita; Nacci, Vito; Fiorini, Isabella; Novellino, Ettore; Cagnotto, Alfredo; Mennini, Tiziana; Sandager-Nielsen, Karin; Andreasen, Jesper Tobias; Scheel-Kruger, Jorgen; Mikkelsen, Jens D.; Fattorusso, Caterina | - | |
| Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors | 1-gen-2008 | Butini, Stefania; Campiani, Giuseppe; Borriello, M.; Gemma, Sandra; Panico, Alessandro; Persico, M.; Catalanotti, B.; Ros, S.; Brindisi, Margherita; Agnusdei, M.; Fiorini, Isabella; Nacci, Vito; Novellino, E.; Belinskaya, T.; Saxena, A.; Fattorusso, C. | - | |
| Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies | 1-gen-2008 | Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Kukreja, G.; Sanna Coccone, Salvatore; Joshi, B.; Persico, M.; Nacci, Vito; Fiorini, Isabella; Novellino, E.; Fattorusso, E; Taglialatela Scafati, O.; Savini, Luisa; Taramelli, D.; Basilico, N.; Parapini, S.; Morace, G.; Yardley, V.; Croft, S.; Coletta, M.; Marini, S.; Fattorusso, Caterina | - | |
| Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents | 1-gen-2008 | Fattorusso, Caterina; Campiani, Giuseppe; Kukreja, Gagan; Persico, Marco; Butini, Stefania; Romano, Maria Pia; Altarelli, Maria; Sindu, Ros; Brindisi, Margherita; Savini, Luisa; Novellino, Ettore; Nacci, Vito; Fattorusso, Ernesto; Parapini, Silvia; Basilico, Nicoletta; Taramelli, Donatella; Yardley, Vanessa; Croft, Simon; Borriello, Marianna; Gemma, Sandra | - | |
| Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore | 1-gen-2007 | Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Joshi, B.; Kukreja, G.; Persico, M.; Catalanotti, B.; Novellino, E.; Fattorusso, E; Nacci, Vito; Savini, Luisa; Taramelli, D.; Basilico, N.; Morace, G.; Yardley, V.; Fattorusso, C. | - | |
| Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites | 1-gen-2006 | Gemma, Sandra; Gabellieri, Emanuele; Huleatt, P.; Fattorusso, C.; Borriello, M.; Catalanotti, B.; Butini, Stefania; De Angelis, M.; Novellino, E.; Nacci, Vito; Belinskaya, T.; Saxena, Ashima; Campiani, Giuseppe | - | |
| Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies | 1-gen-2005 | Campiani, Giuseppe; Butini, Stefania; Fattorusso, Caterina; Frotta, Francesco; Gemma, Sandra; Catalanotti, Bruno; Nacci, Vito; Fiorini, Isabella; Cagnotto, Alfredo; Mereghetti, Ilario; Mennini, Tiziana; Minetti, Patrizia; Di Cesare, M. Assunta; Stasi, M. Antonietta; Di Serio, Stefano; Ghirardi, Orlando; Tinti, Ornella; Carminati, Paolo | - | |
| The pyrrolo-1,5-benzoxazepine,PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumor growth in vivo | 1-gen-2005 | Greene, Lisa M.; Fleeton, Marina; Mulligan, Jude; Gowda, Chikkanna; Sheahan, Brian J.; Atkins, Gregory J.; Campiani, Giuseppe; Nacci, Vito; Lawler, Mark; Williams, D. Clive; Zisterer, Daniela M. | - | |
| Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors | 1-gen-2005 | Campiani, Giuseppe; Fattorusso, C; Butini, Stefania; Gaeta, A; Agnusdei, M; Gemma, Sandra; Persico, M; Catalanotti, B; Savini, Luisa; Nacci, Vito; Novellino, E; Holloway, Hw; Greig, Nh; Belinskaya, T; Fedorko, Jm; Saxena, A. | - | |
| Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 | 1-gen-2005 | Maga, G.; Gemma, Sandra; Fattorusso, C.; Locatelli, G. A.; Butini, Stefania; Persico, M.; Kukreja, G.; Romano, M. P.; Chiasserini, Luisa; Savini, Luisa; Novellino, E.; Nacci, Vito; Spadari, S.; Campiani, Giuseppe | - | |
| Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target | 1-gen-2005 | Mc Gee, M. M.; Gemma, Sandra; Butini, Stefania; Ramunno, A.; Zisterer, D. M.; Fattorusso, C.; Catalanotti, B.; Kukreja, G.; Fiorini, Isabella; Pisano, C.; Cucco, C.; Novellino, E.; Nacci, Vito; Williams, D. C.; Campiani, Giuseppe | - | |
| Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity | 1-gen-2005 | Fattorusso, Caterina; Gemma, Sandra; Butini, Stefania; Huleatt, Paul; Catalanotti, Bruno; Persico, Marco; De Angelis, Meri; Fiorini, Isabella; Nacci, Vito; Ramunno, Anna; Rodriquez, Manuela; Greco, Giovanni; Novellino, Ettore; Bergamini, Alberto; Marini, Stefano; Coletta, Massimo; Maga, Giovanni; Spadari, Silvio; Campiani, Giuseppe | - | |
| Pyrrolo[1,3]benzothiazepine-Based Serotonin and Dopamine Receptor Antagonists. Molecular Modeling, Further Structure-Activity Relationship Studies, and Identification of Novel Atypical Antipsychotic Agents | 1-gen-2004 | Campiani, Giuseppe; Butini, Stefania; Fattorusso, C; Catalanotti, B; Gemma, Sandra; Nacci, Vito; Morelli, E; Cagnotto, A; Mereghetti, I; Mennini, T; Carli, M; Minetti, P; DI CESARE, M. A.; Mastroianni, D; Scafetta, N; Galletti, B; Stasi, M. A.; Castorina, M; Pacifici, L; Vertechy, M; Serio, S. D.; Ghirardi, O; Tinti, O; Carminati, P. | - | |
| Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL | 1-gen-2004 | Mc Gee, Margaret M.; Greene, Lisa M.; Ledwidge, Susan; Campiani, Giuseppe; Nacci, Vito; Lawler, Mark; Williams, D. Clive; Zisterer, Daniela M. | - | |
| Neuronal high affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases | 1-gen-2003 | Campiani, G.; Fattorusso, C.; DE ANGELIS, M.; Catalanotti, B.; Butini, S.; Fattorusso, R.; Fiorini, I.; Nacci, V.; Novellino, E. | - | |
| Novel antipsychotic agents: recent advances in the drug treatment of schizophrenia | 1-gen-2003 | Butini, Stefania; Campiani, Giuseppe; De Angelis, Meri; Fattorusso, Caterina; Nacci, Vito; Fiorini, Isabella | - | |
| Synthesis and Pharmacological Evaluation of Potent and Highly Selective D3 Receptor Ligands: Inhibition of Cocaine-Seeking Behaviour and the Role of Dopamine D3/D2Receptors | 1-gen-2003 | Campiani, G.; Butini, S.; Trotta, F.; Fattorusso, C.; Catalanotti, B.; Aiello, F.; Gemma, S.; Nacci, V.; Novellino, E.; Stark, J. A.; Cagnotto, A.; Fumagalli, E.; Carnovali, F.; Cervo, L.; Mennini, T. | - | |
| Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human astrocytoma cells by the pyrrolo-1,5-benzoxazepine, PBOX-21 | 1-gen-2003 | Mulligan, Jude M.; Campiani, Giuseppe; Ramunno, Anna; Nacci, Vito; Zisterer, Daniela M. | - |
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